| + |
PRKCA | down-regulates 
phosphorylation
|
PEA15 |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137841 |
Ser104 |
TKLTRIPsAKKYKDI |
Homo sapiens |
|
| pmid |
sentence |
| 15917297 |
Pea-15 is phosphorylated on two ser residues, ser104 and ser116. Protein kinase c (pkc) phosphorylates ser104 / we report that phosphorylation of pea-15 blocks its interaction with erk1/2 in vitro and in vivo and that phosphorylation of both ser104 and ser116 is required for this effect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| + |
AKT1 | up-regulates activity 
phosphorylation
|
PEA15 |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102092 |
Ser116 |
KDIIRQPsEEEIIKL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12808093 |
Protein kinase b/akt binds and phosphorylates ped/pea-15, stabilizing its antiapoptotic action. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAMK2G |
phosphorylation
|
PEA15 |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250701 |
Ser116 |
KDIIRQPsEEEIIKL |
|
Astrocyte |
| pmid |
sentence |
| 9721757 |
Partly purified PEA-15 was a substrate in vitro for CaMKII, but not for casein kinase II. Two-dimensional phosphopeptide mapping demonstrated that the site phosphorylated in vitro by CaMKII was also phosphorylated in intact astrocytes in response to endothelin. CaMKII phosphorylated selectively Ser116 and had no effect on Ser104, but in vitro phosphorylation by CaMKII appeared to facilitate further phosphorylation by protein kinase C. |
|
| Publications: |
1 |
| + |
AKT | up-regulates activity
phosphorylation
|
PEA15 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244326 |
Ser116 |
KDIIRQPsEEEIIKL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12808093 |
Protein kinase b/akt binds and phosphorylates ped/pea-15, stabilizing its antiapoptotic action. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAMK2A | up-regulates
phosphorylation
|
PEA15 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137614 |
Ser116 |
KDIIRQPsEEEIIKL |
Homo sapiens |
|
| pmid |
sentence |
| 15916534 |
Pea-15 is a phosphoprotein containing a ser-104 phosphorylated by protein kinase c and a ser-116 phosphorylated by camkii (calcium/calmodulin-dependent protein kinase ii) or akt. Phosphorylation of ser-104 is implicated in the regulation of glucose metabolism, while phosphorylation at ser-116 is required for pea-15 recruitment to the disc (death-initiation signalling complex) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PEA15 | down-regulates 
|
ERK1/2 |
0.862 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269925 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11702783 |
Here, we report that pea-15, a protein variably expressed in multiple cell types, blocks erk-dependent transcription and proliferation by binding erks and preventing their localization in the nucleus._ Pea-15 can redirect the biological outcome of map kinase signaling by regulating the subcellular localization of erk map kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX3 | down-regulates quantity by repression
transcriptional regulation
|
PEA15 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255097 |
|
|
Homo sapiens |
MKN-1 Cell |
| pmid |
sentence |
| 17956589 |
Comprehensive analysis using a cDNA microarray showed that RUNX3 upregulated 17 apoptosis-related genes (including FADD, TRAF6, caspase-2, ING1, ING4, Calpain 10, and DNase1) and downregulated 135 apoptosis-related genes (including FLIP, PEA15, TXN2, HSPD1, IKK, and TIAL1) in MKN-1 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PEA15 | down-regulates
|
MAPK1 |
0.862 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111499 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11702783 |
Here, we report that pea-15, a protein variably expressed in multiple cell types, blocks erk-dependent transcription and proliferation by binding erks and preventing their localization in the nucleus._ Pea-15 can redirect the biological outcome of map kinase signaling by regulating the subcellular localization of erk map kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HTRA2 | down-regulates
binding
|
PEA15 |
0.498 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126966 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15328349 |
Htra2 promotes cell death by binding and degrading the anti-apoptotic protein pea15 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PEA15 | down-regulates
|
MAPK3 |
0.758 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111502 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11702783 |
Here, we report that pea-15, a protein variably expressed in multiple cell types, blocks erk-dependent transcription and proliferation by binding erks and preventing their localization in the nucleus._ Pea-15 can redirect the biological outcome of map kinase signaling by regulating the subcellular localization of erk map kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PEA15 | down-regulates
|
Gbeta |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269904 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11702783 |
Here, we report that pea-15, a protein variably expressed in multiple cell types, blocks erk-dependent transcription and proliferation by binding erks and preventing their localization in the nucleus._ Pea-15 can redirect the biological outcome of map kinase signaling by regulating the subcellular localization of erk map kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PEA15
- 
- 