Summary

Name PEA15
Full Name Astrocytic phosphoprotein PEA-15
Synonyms 15 kDa phosphoprotein enriched in astrocytes, Phosphoprotein enriched in diabetes, PED
Primary ID Q15121
Links - -
Type protein
Relations 11
Function Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation PEA15 0.394
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png phosphorylation PEA15 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PEA15 0.537
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PEA15 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PEA15 0.351
Publications: 1
+ down-regulates img/direct_inhibition.png binding PEA15 0.502
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Gbeta 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png ERK1/2 0.859
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PEA15 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png MAPK1 0.859
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png MAPK3 0.754
Publications: 1 Organism: Homo Sapiens