| + |
MAPK1 | up-regulates 
phosphorylation
|
NCOA1 |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74872 |
Ser1185 |
GTPPASTsPFSQLAA |
Homo sapiens |
|
| pmid |
sentence |
| 10660621 |
Furthermore, erk-2 phosphorylated threonine 1179 and serine 1185 (and to a lesser extent, serine 395) in vitro, suggesting the importance of this pathway for src-1 regulation. Treatment of cells expressing src-1 with epidermal growth factor enhanced the ligand-dependent, progesterone receptor-mediated activation of a target reporter gene. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74876 |
Ser395 |
PSVNPSIsPAHGVAR |
Homo sapiens |
|
| pmid |
sentence |
| 10660621 |
Furthermore, erk-2 phosphorylated threonine 1179 and serine 1185 (and to a lesser extent, serine 395) in vitro, suggesting the importance of this pathway for src-1 regulation. Treatment of cells expressing src-1 with epidermal growth factor enhanced the ligand-dependent, progesterone receptor-mediated activation of a target reporter gene. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74880 |
Thr1179 |
NYGTNPGtPPASTSP |
Homo sapiens |
|
| pmid |
sentence |
| 10660621 |
Furthermore, erk-2 phosphorylated threonine 1179 and serine 1185 (and to a lesser extent, serine 395) in vitro, suggesting the importance of this pathway for src-1 regulation. Treatment of cells expressing src-1 with epidermal growth factor enhanced the ligand-dependent, progesterone receptor-mediated activation of a target reporter gene. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Glucocorticoid receptor Signaling |
| + |
MAPK3 | up-regulates
phosphorylation
|
NCOA1 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-91139 |
Ser1185 |
GTPPASTsPFSQLAA |
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 12163482 |
Mapk also directly phosphorylates src-1 at thr1179 and ser1185. Phosphorylation of src-1 by mitogen-activated protein kinase (mapk) is required for optimal progesterone receptor-dependent transcription and for functional cooperation with camp response element-binding protein-binding protein |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-91143 |
Thr1179 |
NYGTNPGtPPASTSP |
Homo sapiens |
|
| pmid |
sentence |
| 12163482 |
Mapk also directly phosphorylates src-1 at thr1179 and ser1185. Phosphorylation of src-1 by mitogen-activated protein kinase (mapk) is required for optimal progesterone receptor-dependent transcription and for functional cooperation with camp response element-binding protein-binding protein |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Glucocorticoid receptor Signaling |
| + |
NCOA1 | up-regulates
binding
|
STAT5A |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100258 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12954634 |
Ncoa-1/src-1 is an essential coactivator of stat5 that binds to the fdl motif in the alpha-helical region of the stat5 transactivation domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| Pathways: | Acute Myeloid Leukemia, Glucocorticoid receptor Signaling |
| + |
Gbeta | up-regulates
phosphorylation
|
NCOA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270099 |
|
|
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 12163482 |
Mapk also directly phosphorylates src-1 at thr1179 and ser1185. Phosphorylation of src-1 by mitogen-activated protein kinase (mapk) is required for optimal progesterone receptor-dependent transcription and for functional cooperation with camp response element-binding protein-binding protein |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA1 | up-regulates quantity by expression 
transcriptional regulation
|
PCK2 |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255066 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA1 | up-regulates quantity by expression
transcriptional regulation
|
RARA |
0.696 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255932 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16606617 |
We also show that ASXL1 associates specifically with SRC-1 and cooperates synergistically in the transcriptional activation. Further data indicated that the transactivation domain (AD; amino acids 300–655) of ASXL1, newly defined in this study, interacts with the C-terminal AD2 (amino acids 1217–1441) of SRC-1, suggesting that one AD cooperates with the other AD in transcriptional activation by RAR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML |
| + |
NCOA1 | up-regulates quantity by expression
transcriptional regulation
|
CYP7A1 |
0.451 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255063 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA1 | up-regulates quantity by expression
transcriptional regulation
|
OTC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255062 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates
phosphorylation
|
NCOA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270194 |
|
|
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 12163482 |
Mapk also directly phosphorylates src-1 at thr1179 and ser1185. Phosphorylation of src-1 by mitogen-activated protein kinase (mapk) is required for optimal progesterone receptor-dependent transcription and for functional cooperation with camp response element-binding protein-binding protein |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
NCOA1 | up-regulates quantity by expression
transcriptional regulation
|
APOC3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255065 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA1 | up-regulates
binding
|
STAT5B |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100261 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12954634 |
Ncoa-1/src-1 is an essential coactivator of stat5 that binds to the fdl motif in the alpha-helical region of the stat5 transactivation domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| + |
NCOA1 | up-regulates quantity by expression
transcriptional regulation
|
APOA5 |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255064 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA1 | up-regulates
binding
|
ESR1 |
0.839 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-54442 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9427757 |
Steroid receptor co-activator (src1) is one of a number of transcriptional co-activators that are capable of potentiating the activity of nuclear receptors including the oestrogen receptor (er). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | up-regulates quantity by expression
transcriptional regulation
|
NCOA1 |
0.76 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251682 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9590696 |
Transactivation of these templates depends on the association of the GR with co-activators such as SRC-1/NcoA1, GRIP-1/TIF-2/NcoA2 and p300/CBP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glucocorticoid receptor Signaling |
| + |
PTMS | up-regulates activity
binding
|
NCOA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268462 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16150697 |
Macromolecular translocation inhibitor II (MTI-II), which was first identified as an in vitro inhibitor of binding between the highly purified glucocorticoid receptor (GR) and isolated nuclei, is an 11.5-kDa Zn2+-binding protein that is also known as ZnBP or parathymosin. MTI-II Enhances GR-dependent Transcription through Its Acidic Domain. MTI-II Enhances GR-dependent Transcription in Cooperation with SRC-1 and p300 in Vivo. CBP and p300 Coprecipitate with MTI-II in a Glucocorticoid Hormone-dependent Manner. Immunoprecipitation analysis showed that in the presence of glucocorticoid hormone, p300 and CREB-binding protein are coprecipitated with MTI-II. Furthermore, the knockdown of endogenous MTI-II by RNAi reduces the transcriptional activity of GR in cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA1 | up-regulates quantity by expression
transcriptional regulation
|
ALDOB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255061 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA1 | up-regulates quantity by expression
transcriptional regulation
|
Aldolase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270223 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA1 | up-regulates
|
PGR |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70149 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10449719 |
Progesterone receptor (pr) functions as a transcription factor that modulates the transcription of target genes in response to progesterone and other signals. The transcriptional activity of pr requires the involvement of coactivators such as steroid receptor coactivator-1 (src-1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA1 | up-regulates activity
binding
|
ASXL1 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255924 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16606617 |
We also show that ASXL1 associates specifically with SRC-1 and cooperates synergistically in the transcriptional activation.Therefore, both the ability to bind SRC-1 and the autonomous activation of ASXL1 are required for its coactivator function. Further data indicated that the transactivation domain (AD; amino acids 300–655) of ASXL1, newly defined in this study, interacts with the C-terminal AD2 (amino acids 1217–1441) of SRC-1, suggesting that one AD cooperates with the other AD in transcriptional activation by RAR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML |
| + |
ASXL1 | up-regulates activity
binding
|
NCOA1 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255931 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16606617 |
We also show that ASXL1 associates specifically with SRC-1 and cooperates synergistically in the transcriptional activation. Further data indicated that the transactivation domain (AD; amino acids 300–655) of ASXL1, newly defined in this study, interacts with the C-terminal AD2 (amino acids 1217–1441) of SRC-1, suggesting that one AD cooperates with the other AD in transcriptional activation by RAR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML |
3.0
NCOA1
- 
- 