| + |
PRKACA | down-regulates 
phosphorylation
|
NOXA1 |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163663 |
Ser172 |
DQVQRRGsLPPRQVP |
Homo sapiens |
|
| pmid |
sentence |
| 20110267 |
We identified ser-282 as target of mapk and ser-172 as target of pkc and pka in vitro and in a transfected human embryonic kidney 293 (hek293) cell model using site directed mutagenesis and phosphopeptide mapping analysis. In hek293 cells, phosphorylation of these sites occurred at a basal level and down-regulated constitutive nox1 activity. I |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PKA | down-regulates activity
phosphorylation
|
NOXA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264712 |
Ser172 |
DQVQRRGsLPPRQVP |
Homo sapiens |
Colonic Epithelium Cell Line |
| pmid |
sentence |
| 20943948 |
On the other hand, our group has shown that protein kinase A (PKA) inhibits Nox1 activity in colon epithelial cells by phosphorylating NoxA1 at two distinct sites, Ser172 and Ser461 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264713 |
Ser461 |
VPAGPRMsGAPGRLP |
Homo sapiens |
Colonic Epithelium Cell Line |
| pmid |
sentence |
| 20943948 |
On the other hand, our group has shown that protein kinase A (PKA) inhibits Nox1 activity in colon epithelial cells by phosphorylating NoxA1 at two distinct sites, Ser172 and Ser461 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKCA | down-regulates
phosphorylation
|
NOXA1 |
0.294 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163667 |
Ser172 |
DQVQRRGsLPPRQVP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20110267 |
Phosphorylation of nadph oxidase activator 1 (noxa1) on serine 282 by map kinases and on serine 172 by protein kinase c and protein kinase a prevents nox1 hyperactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | down-regulates
phosphorylation
|
NOXA1 |
0.331 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164227 |
Ser282 |
VGKQAPLsPGLPAMG |
Homo sapiens |
|
| pmid |
sentence |
| 20230789 |
Accumulating evidence indicates that protein phosphorylation regulates nox activity. In this report, we show that serine282 residue of nox activator 1 (noxa1) is phosphorylated by erk in response to egf resulting in desensitization of nox1 activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163659 |
Ser282 |
VGKQAPLsPGLPAMG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20110267 |
These results demonstrated a critical role of noxa1 phosphorylation on ser-282 and ser-172 in preventing nox1 hyperactivation through the decrease of noxa1 interaction to nox1 and rac1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | down-regulates
phosphorylation
|
NOXA1 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164231 |
Ser282 |
VGKQAPLsPGLPAMG |
Homo sapiens |
|
| pmid |
sentence |
| 20230789 |
Accumulating evidence indicates that protein phosphorylation regulates nox activity. In this report, we show that serine282 residue of nox activator 1 (noxa1) is phosphorylated by erk in response to egf resulting in desensitization of nox1 activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | up-regulates 
phosphorylation
|
NOXA1 |
0.419 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168545 |
Tyr110 |
RGHAAIDyTQLGLRF |
Homo sapiens |
|
| pmid |
sentence |
| 20943948 |
Here, we show that the interaction of noxa1 and tks proteins is dependent on src activity. Interestingly, the abolishment of src-mediated phosphorylation of tyr110 on noxa1 and of tyr508 on tks4 blocks their binding and decreases nox1-dependent ros generation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP53 | up-regulates quantity by expression
transcriptional regulation
|
NOXA1 |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209687 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19879762 |
As a transcription factor, p53 induces several pro-apoptotic Bcl-2 members including Bax, Puma, Noxa and Bid, and represses the transcription of certain anti-apoptotic genes, including those encoding Bcl-2, Bcl-xL and survivin 3_and_5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Mitochondrial Control of Apoptosis |
| + |
SH3PXD2B | up-regulates activity
binding
|
NOXA1 |
0.355 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264707 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20943948 |
Tks4 and Tks5 bind NoxA1 through their SH3 domains in a Rac-independent manner|NoxO1 is required for full Nox1 and Nox3 oxidase activity at least partially because of its role in the plasma membrane recruitment of the NoxA1 activator protein|Tks4 and Tks5 support Nox1- and Nox3-dependent ROS generation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | down-regulates
phosphorylation
|
NOXA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270203 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20230789 |
Accumulating evidence indicates that protein phosphorylation regulates nox activity. In this report, we show that serine282 residue of nox activator 1 (noxa1) is phosphorylated by erk in response to egf resulting in desensitization of nox1 activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOXO1 | up-regulates activity
relocalization
|
NOXA1 |
0.77 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264709 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20943948 |
Tks4 and Tks5 bind NoxA1 through their SH3 domains in a Rac-independent manner|NoxO1 is required for full Nox1 and Nox3 oxidase activity at least partially because of its role in the plasma membrane recruitment of the NoxA1 activator protein|Tks4 and Tks5 support Nox1- and Nox3-dependent ROS generation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | down-regulates
phosphorylation
|
NOXA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270114 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20230789 |
Accumulating evidence indicates that protein phosphorylation regulates nox activity. In this report, we show that serine282 residue of nox activator 1 (noxa1) is phosphorylated by erk in response to egf resulting in desensitization of nox1 activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOXA1 | up-regulates activity
binding
|
NOX3 |
0.618 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264711 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20943948 |
Tks4 and Tks5 bind NoxA1 through their SH3 domains in a Rac-independent manner|NoxO1 is required for full Nox1 and Nox3 oxidase activity at least partially because of its role in the plasma membrane recruitment of the NoxA1 activator protein|Tks4 and Tks5 support Nox1- and Nox3-dependent ROS generation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOXA1 | up-regulates activity
binding
|
NOX1 |
0.743 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264710 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20943948 |
Tks4 and Tks5 bind NoxA1 through their SH3 domains in a Rac-independent manner|NoxO1 is required for full Nox1 and Nox3 oxidase activity at least partially because of its role in the plasma membrane recruitment of the NoxA1 activator protein|Tks4 and Tks5 support Nox1- and Nox3-dependent ROS generation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOXA1 | down-regulates activity
|
BCL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209684 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19879762 |
BH3-only proteins containing only a single BH domain and including Puma, Noxa, Bid and Bad as well as other factors are particularly important for such neutralisation, binding and regulating the anti-apoptotic Bcl-2 proteins to promote apoptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Mitochondrial Control of Apoptosis |
| + |
SH3PXD2A | up-regulates activity
binding
|
NOXA1 |
0.42 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264708 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20943948 |
Tks4 and Tks5 bind NoxA1 through their SH3 domains in a Rac-independent manner|NoxO1 is required for full Nox1 and Nox3 oxidase activity at least partially because of its role in the plasma membrane recruitment of the NoxA1 activator protein|Tks4 and Tks5 support Nox1- and Nox3-dependent ROS generation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NOXA1
- 
- 