| + |
MAPK1 | up-regulates 
phosphorylation
|
ABI1 |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172869 |
Ser183 |
PPTQKPPsPPMSGRG |
Homo sapiens |
|
| pmid |
sentence |
| 21419341 |
Our mass spectrometry also identified abi1 s183 and s225 on abi1 (numbering corresponds to abi1 isoform 1) as sites phosphorylated on endogenous protein and in the wildtype erk-dependent in vitro phosphorylated sample. these data indicate erk phosphorylation of abi1 is required for basal and egf-induced wrc interaction with the wrp2/3 complex. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172873 |
Ser222 |
TSPARLGsQHSPGRT |
Homo sapiens |
|
| pmid |
sentence |
| 21419341 |
Our mass spectrometry also identified abi1 s183 and s225 on abi1 (numbering corresponds to abi1 isoform 1) as sites phosphorylated on endogenous protein and in the wildtype erk-dependent in vitro phosphorylated sample. these data indicate erk phosphorylation of abi1 is required for basal and egf-induced wrc interaction with the wrp2/3 complex. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172877 |
Ser225 |
ARLGSQHsPGRTASL |
Homo sapiens |
|
| pmid |
sentence |
| 21419341 |
We show that erk colocalizes with the wrc at lamellipodial leading edges and directly phosphorylates two wrc components: wave2 and abi1. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
PTEN | down-regulates quantity by destabilization 
dephosphorylation
|
ABI1 |
0.242 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276949 |
Ser216 |
VPNDYMTsPARLGSQ |
Homo sapiens |
|
| pmid |
sentence |
| 32673396 |
After dephosphorylation by PTEN, Abi1 is degraded by calpains.|We demonstrate that PTEN dephosphorylation of Abi1 at Y213 and S216 results in Abi1 degradation through the calpain pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276948 |
Tyr213 |
PPTVPNDyMTSPARL |
Homo sapiens |
|
| pmid |
sentence |
| 32673396 |
After dephosphorylation by PTEN, Abi1 is degraded by calpains.|We demonstrate that PTEN dephosphorylation of Abi1 at Y213 and S216 results in Abi1 degradation through the calpain pathway. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDK1 | down-regulates activity
phosphorylation
|
ABI1 |
0.42 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264421 |
Ser216 |
VPNDYMTsPARLGSQ |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21900237 |
We identified serine 216 of Abi1 as a target of CDK1/cyclin B kinase that is phosphorylated in cells at the onset of mitosis.|Bcr-Abl-induced actin polymerization requires the Abi1 pathway, as the blockade of the signal transduction from Bcr-Abl to Abi1 abolishes the F-actin assembly|serine phosphorylation of Abi1 by CDK1/cyclin B serves as a cell cycle-dependent regulatory mechanism that inhibits actin assembly |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinB/CDK1 | down-regulates activity
phosphorylation
|
ABI1 |
0.42 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264452 |
Ser216 |
VPNDYMTsPARLGSQ |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21900237 |
We identified serine 216 of Abi1 as a target of CDK1/cyclin B kinase that is phosphorylated in cells at the onset of mitosis.|Bcr-Abl-induced actin polymerization requires the Abi1 pathway, as the blockade of the signal transduction from Bcr-Abl to Abi1 abolishes the F-actin assembly|serine phosphorylation of Abi1 by CDK1/cyclin B serves as a cell cycle-dependent regulatory mechanism that inhibits actin assembly |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates
phosphorylation
|
ABI1 |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172881 |
Ser225 |
ARLGSQHsPGRTASL |
Homo sapiens |
|
| pmid |
sentence |
| 21419341 |
We show that erk colocalizes with the wrc at lamellipodial leading edges and directly phosphorylates two wrc components: wave2 and abi1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL1 | up-regulates
phosphorylation
|
ABI1 |
0.88 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172017 |
Tyr213 |
PPTVPNDyMTSPARL |
Homo sapiens |
|
| pmid |
sentence |
| 21320496 |
Abi-1 is an adaptor protein for abelson kinase (c-abl). Here, we identified a new phosphorylation site (y398) in the sh3 domain of abi1, and disruption of y398, combined with the previously identified phosphorylation site y213, significantly weakens the binding of abi-1 to c-abl. Phosphorylation of abi-1 is dependent on c-abl kinase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | up-regulates
phosphorylation
|
ABI1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270048 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21419341 |
We show that erk colocalizes with the wrc at lamellipodial leading edges and directly phosphorylates two wrc components: wave2 and abi1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABI1 | up-regulates
binding
|
CBL |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154162 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17395426 |
Here we uncover a novel interaction between abi-1 and the cbl ubiquitin ligase and show that abi-1 mediates cbl accumulation to the plasma membrane upon stimulation by egf. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABI1 | up-regulates
binding
|
ABL1 |
0.88 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45994 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9010225 |
Our results are in agreement with previous report showing that abi-1, the putative mouse homologue of e3b1, is a abl binding protein |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABI1 | form complex 
binding
|
WRC complex |
0.846 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253571 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21107423 |
WAVE proteins are constitutively associated with four additional proteins in cells: Sra1/Cyfip1, Nap1/Hem-2, Abi and HSPC300. The components of this ~400 kDa pentamer, termed the WAVE regulatory complex (WRC) have all been implicated in control of Arp2/3 complex-mediated actin assembly in a wide range of systems |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABI1 | form complex
binding
|
WAVE complex |
0.861 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261872 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15070726 |
Here we purify Wave-2 from HeLa cells. Five proteins, Sra, Nap, Wave-2, Abi, and Hspc, are copurified, indicating that they form a tight complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates
phosphorylation
|
ABI1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270161 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21419341 |
We show that erk colocalizes with the wrc at lamellipodial leading edges and directly phosphorylates two wrc components: wave2 and abi1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DTNBP1 | up-regulates activity
binding
|
ABI1 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265660 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 20531346 |
Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation. Although dysbindin-1, WAVE2 and Abi-1 form a ternary complex, dysbindin-1 promoted the binding of WAVE2 to Abi-1. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Tissue: |
Hippocampus |
4.0
ABI1
- 
- 