Summary

Name HIPK2
Full Name Homeodomain-interacting protein kinase 2
Synonyms hHIPk2
Primary ID Q9H2X6
Links - -
Type protein
Relations 29
Pathways Cell cycle: G2/M phase transition, Rett syndrome
Function Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CDKN1B 0.258
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates activity img/direct_inhibition.png phosphorylation HIPK2 0.251
Publications: 3
+ down-regulates activity img/direct_inhibition.png phosphorylation HIPK2 0.2
Publications: 3
+ up-regulates img/direct-activation.png phosphorylation CREB1 0.404
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ img/unknown.png phosphorylation PDX1 0.365
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation HMGA1 0.512
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PML 0.452
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTBP1 0.489
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.791
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PPM1D 0.437
Publications: 2
+ up-regulates activity img/direct-activation.png phosphorylation MECP2 0.495
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ up-regulates activity img/direct-activation.png phosphorylation PAX6 0.479
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ZBTB4 0.388
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation HIPK2 0.413
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination HIPK2 0.315
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination HIPK2 0.591
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ down-regulates quantity by destabilization img/direct_inhibition.png binding HIPK2 0.416
Publications: 1 Organism: Homo Sapiens