3.0
Myoblast: IL6 and hypertrophy
Pathway ID: SIGNOR-MyocIL6HYPER
Description: IL6 is an essential regulator of satellite cell-mediated hypertrophic muscle growth. Circulating IL6 levels normally peak immediately following acute physical exercise and return to baseline levels few days later. Depending on its concentration, IL6 plays an important role in the regulation of satellite cell proliferation. At lower concentrations, IL6 induces a dose-dependent boost of satellite cell proliferation by activating the JAK2/STAT3 pathway. Upon STAT3 activation, increased expression of cyclin D1 and c-myc promotes satellite cell progression through the cell cycle. At higher IL6 concentrations, STAT3 activation can be also related to MYOD1 expression and the progression towards terminal myogenic differentiation.
Curated by: Andrea Cerquone Perpetuini
Description: IL6 is an essential regulator of satellite cell-mediated hypertrophic muscle growth. Circulating IL6 levels normally peak immediately following acute physical exercise and return to baseline levels few days later. Depending on its concentration, IL6 plays an important role in the regulation of satellite cell proliferation. At lower concentrations, IL6 induces a dose-dependent boost of satellite cell proliferation by activating the JAK2/STAT3 pathway. Upon STAT3 activation, increased expression of cyclin D1 and c-myc promotes satellite cell progression through the cell cycle. At higher IL6 concentrations, STAT3 activation can be also related to MYOD1 expression and the progression towards terminal myogenic differentiation.
Curated by: Andrea Cerquone Perpetuini
10 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| IL6R | P08887 |
| MYOD1 | P15172 |
| IL6ST | P40189 |
| Proliferation | SIGNOR-PH4 |
| Differentiation | SIGNOR-PH37 |
| CCND1 | P24385 |
| JAK2 | O60674 |
| MYC | P01106 |
| STAT3 | P40763 |
| IL6 | P05231 |