Satellite: Myostatin

Pathway ID: SIGNOR-SM

Description: Myostatin regulates muscle differentiation via SMAD2 and SMAD3 while follistatin counterbalances this negative modulation. Myostatin binds its receptor ActRIIB. Activated receptor phosphorylates SMAD2 or SMAD3. Phosphorylated SMADs form a heterocomplex with SMAD4 and translocate into the nucleus where they interfere with MYOD1 transcriptional activity and expression. This inhibition results in myogenic differentiation failure.

Curated by: Gianni Cesareni

10 Seed Entities

Organism:
Name Primary ID
FST P19883
SMAD2/SMAD4 SIGNOR-C8
MYOD1 P15172
ACVR2B Q13705
SMAD3/SMAD4 SIGNOR-C9
SMAD2 Q15796
Skeletal_muscle_differentiation SIGNOR-PH1
SMAD4 Q13485
MSTN O14793
SMAD3 P84022