| + |
AKT | down-regulates 
phosphorylation
|
FOXO6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-66032 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18394876 |
The phosphorylation of the two remaining akt-dependent sites inhibits foxo6 transcriptional activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFIX | down-regulates quantity
transcriptional regulation
|
FOXO6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268887 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO6 | up-regulates quantity by expression 
transcriptional regulation
|
FBXO32 |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236560 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Foxo factors are required for the transcriptional regulation of the ubiquitin ligases atrogin-1, also called muscle atrophy f-box (mafbx) and muscle ring finger 1 (murf1), leading to the ubiquitylation of myosin and other muscle proteins, and their degradation via the proteasome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
FOXO6 | up-regulates quantity by expression
transcriptional regulation
|
TRIM63 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236567 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Foxo factors are required for the transcriptional regulation of the ubiquitin ligases atrogin-1, also called muscle atrophy f-box (mafbx) and muscle ring finger 1 (murf1), leading to the ubiquitylation of myosin and other muscle proteins, and their degradation via the proteasome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
AKT1 | down-regulates
phosphorylation
|
FOXO6 |
0.636 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175294 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Akt inactivates protein degradation by phosphorylating and thus repressing the transcription factors of the foxo family, and stimulates protein synthesis via the mammalian target of rapamycin (mtor) and glycogen synthase kinase 3b (gsk3b). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252582 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18394876 |
The phosphorylation of the two remaining akt-dependent sites inhibits foxo6 transcriptional activity |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FOXO6 | up-regulates quantity by expression 
transcriptional regulation
|
IDH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260092 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25648147 |
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260103 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25648147 |
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
DYRK1A | down-regulates
phosphorylation
|
FOXO6 |
0.313 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183680 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFIA | down-regulates quantity
transcriptional regulation
|
FOXO6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268875 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CSNK1A1 | down-regulates
phosphorylation
|
FOXO6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183667 |
|
|
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFIB | down-regulates quantity
transcriptional regulation
|
FOXO6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268881 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
FOXO6
- 
- 