| + |
lysophosphatidic acids | up-regulates 
chemical activation
|
LPAR1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138582 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16014605 |
Lpa exerts its downstream signaling by binding to the lpa(1), lpa(2), and lpa(3) (formerly edg-2, -4, and -7) family of seven-transmembrane, segmented, heterotrimeric guanine nucleotide-binding protein (g protein)-coupled receptors. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-37365 |
|
|
Rattus norvegicus |
Rat-1 Cell |
| pmid |
sentence |
| 8276865 |
LPA activates its own G protein-coupled receptor(s) leading to stimulation of phospholipase C and inhibition of adenylate cyclase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198523 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22863277 |
Lpa binds to a family of gpcrs known as lpa receptors (lpa1-6) to initiate intracellular signaling. Lpa1 was highly expressed and lpa3 was detectable in hek293a cells compared to other lpa receptors. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, Rattus Norvegicus |
| + |
lysophosphatidic acids | up-regulates
chemical activation
|
LPAR3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138585 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16014605 |
Lpa exerts its downstream signaling by binding to the lpa(1), lpa(2), and lpa(3) (formerly edg-2, -4, and -7) family of seven-transmembrane, segmented, heterotrimeric guanine nucleotide-binding protein (g protein)-coupled receptors. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-36389 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8276865 |
Lpa activates its own g protein-coupled receptor(s). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198526 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22863277 |
Lpa binds to a family of gpcrs known as lpa receptors (lpa1-6) to initiate intracellular signaling. Lpa1 was highly expressed and lpa3 was detectable in hek293a cells compared to other lpa receptors. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
lysophosphatidic acids | up-regulates
chemical activation
|
LPAR2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-37368 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8276865 |
Lpa activates its own g protein-coupled receptor(s) leading to stimulation of phospholipase c and inhibition of adenylate cyclase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
lysophosphatidic acids | down-regulates 
|
LATS1/2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269868 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 22863277 |
Serum-borne lysophosphatidic acid (lpa) and sphingosine 1-phosphophate (s1p) act through g12/13-coupled receptors to inhibit the hippo pathway kinases lats1/2, thereby activating yap and taz transcription coactivators, which are oncoproteins repressed by lats1/2. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
lysophosphatidic acids | up-regulates
chemical activation
|
GNB3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152759 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
Lpa through galfai and gbetagamma subunits also activates phosphatidylinositol 3-kinase (pi3k), which results in the stimulation of the akt survival pathway and increased protein translation by the activation of the mammalian target of rapamycin (mtor) pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
lysophosphatidic acids | down-regulates
|
LATS1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198517 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22863277 |
Serum-borne lysophosphatidic acid (lpa) and sphingosine 1-phosphophate (s1p) act through g12/13-coupled receptors to inhibit the hippo pathway kinases lats1/2, thereby activating yap and taz transcription coactivators, which are oncoproteins repressed by lats1/2. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
lysophosphatidic acids | down-regulates
|
LATS2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198520 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 22863277 |
Serum-borne lysophosphatidic acid (lpa) and sphingosine 1-phosphophate (s1p) act through g12/13-coupled receptors to inhibit the hippo pathway kinases lats1/2, thereby activating yap and taz transcription coactivators, which are oncoproteins repressed by lats1/2. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
lysophosphatidic acids