| + |
metformin | up-regulates quantity by expression 
|
G6P |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267789 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
In this study, we found that metformin increased shp gene expression via ampk activation and inhibited the expression of the hepatic gluconeogenic genes pepck and g6pase via upregulation of shp. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270254 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
In this study, we found that metformin increased shp gene expression via ampk activation and inhibited the expression of the hepatic gluconeogenic genes pepck and g6pase via upregulation of shp. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
metformin | up-regulates activity
|
PRKAA1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241952 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 11602624 |
Using a novel AMPK inhibitor, we find that AMPK activation is required for metformins inhibitory effect on glucose production by hepatocytes. In isolated rat skeletal muscles, metformin stimulates glucose uptake coincident with AMPK activation |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
metformin | down-regulates activity 
chemical inhibition
|
NDUFS1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261080 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24843020 |
In this study, we report that in human cancer cells, metformin inhibits mitochondrial complex I (NADH dehydrogenase) activity and cellular respiration |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
metformin | down-regulates 
|
CRTC2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166361 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
It has been proposed that metformin stimulates crtc2 phosphorylation in response to metabolic signals such as energy stress through the lkb1-ampk/sik1 pathways, which promotes binding to 14-3-3 proteins, thereby sequestering crtc2 from the nucleus to the cytoplasm |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142207 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
It has been proposed that metformin stimulates crtc2 phosphorylation in response to metabolic signals such as energy stress through the lkb1-ampk/sik1 pathways, which promotes binding to 14-3-3 proteins, thereby sequestering crtc2 from the nucleus to the cytoplasm |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
metformin | up-regulates quantity by expression
|
NR0B2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158068 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
As shown in fig. 3a, metformin (0.5 to 2 mmol/l) induced shp gene expression and repressed the camp/dex-induced expression of pepck and g6pase in a dose-dependent manner in h4iie cells |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158059 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
In this study, we found that metformin increased shp gene expression via ampk activation and inhibited the expression of the hepatic gluconeogenic genes pepck and g6pase via upregulation of shp. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
metformin | up-regulates quantity by expression
|
G6PC1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158056 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
In this study, we found that metformin increased shp gene expression via ampk activation and inhibited the expression of the hepatic gluconeogenic genes pepck and g6pase via upregulation of shp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
metformin | down-regulates quantity
|
PCK1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158062 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
In this study, we found that metformin increased shp gene expression via ampk activation and inhibited the expression of the hepatic gluconeogenic genes pepck and g6pase via upregulation of shp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
metformin | up-regulates
|
PRKAA2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111034 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11602624 |
Here we report that metformin activates ampk in hepatocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
metformin
