| + |
metformin | up-regulates quantity by expression 
transcriptional regulation
|
G6P |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267789 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
In this study, we found that metformin increased shp gene expression via ampk activation and inhibited the expression of the hepatic gluconeogenic genes pepck and g6pase via upregulation of shp. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270254 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
In this study, we found that metformin increased shp gene expression via ampk activation and inhibited the expression of the hepatic gluconeogenic genes pepck and g6pase via upregulation of shp. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FOXO | up-regulates quantity by expression
transcriptional regulation
|
G6P |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270252 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO1 | up-regulates quantity by expression
transcriptional regulation
|
G6P |
0.33 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267787 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270251 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | up-regulates quantity 
transcriptional regulation
|
G6P |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267792 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270258 |
|
|
Pongo pygmaeus |
HeLa Cell |
| pmid |
sentence |
| 26652733 |
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Pongo Pygmaeus |
| + |
CREB1 | up-regulates quantity
transcriptional regulation
|
G6P |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267786 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270250 |
|
|
Pongo pygmaeus |
HeLa Cell |
| pmid |
sentence |
| 26652733 |
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Pongo Pygmaeus |
| + |
HNF4A | up-regulates quantity by expression
transcriptional regulation
|
G6P |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270255 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267790 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
G6P | down-regulates quantity 
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266571 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12093795 |
Glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, is anchored to the endoplasmic reticulum by nine transmembrane helices. The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176). During catalysis, a His residue in G6Pase becomes phosphorylated generating an enzyme-phosphate intermediate. Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
CRTC2 | up-regulates quantity
transcriptional regulation
|
G6P |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270253 |
|
|
Pongo pygmaeus |
HeLa Cell |
| pmid |
sentence |
| 26652733 |
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267788 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB |
|
| Publications: |
2 |
Organism: |
Pongo Pygmaeus, Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
G6P | up-regulates quantity
chemical modification
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266567 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12093795 |
Glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, is anchored to the endoplasmic reticulum by nine transmembrane helices. The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176). During catalysis, a His residue in G6Pase becomes phosphorylated generating an enzyme-phosphate intermediate. Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
PRKAA1 | down-regulates quantity by repression 
transcriptional regulation
|
G6P |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270257 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21892142 |
Collectively, these findings suggest ampk suppresses glucose production through two transcriptional effects:reduced expression of creb targets via crtc inactivation and reduced expression of foxo target genes via class iia hdac inactivation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | up-regulates quantity by expression
transcriptional regulation
|
G6P |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267791 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
As shown in fig. 3a, metformin (0.5 to 2 mmol/l) induced shp gene expression and repressed the camp/dex-induced expression of pepck and g6pase in a dose-dependent manner in h4iie cells |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270256 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
As shown in fig. 3a, metformin (0.5 to 2 mmol/l) induced shp gene expression and repressed the camp/dex-induced expression of pepck and g6pase in a dose-dependent manner in h4iie cells |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
G6P