| + |
FLT3 | up-regulates activity 
|
Hexokinase |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270268 |
|
|
Homo sapiens |
Acute Lymphoblastic Leukemia Cell Line |
| pmid |
sentence |
| 28194038 |
FLT3/ITD causes a significant increase in aerobic glycolysis through AKT-mediated upregulation of mitochondrial hexokinase (HK2), and renders the leukemia cells highly dependent on glycolysis and sensitive to pharmacological inhibition of glycolytic activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Hexokinase | up-regulates activity
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270310 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18350175 |
The first step in metabolism of glucose (Glc) is usually phosphorylation, catalyzed by hexokinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRAF6 | down-regulates quantity 
ubiquitination
|
Hexokinase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270271 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 28980855 |
The Lys63-linked ubiquitination of HK2 catalyzed by the E3 ligase TRAF6 was critical for the subsequent recognition of HK2 by the autophagy receptor protein SQSTM1/p62 for the process of selective autophagic degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BACH1 | up-regulates quantity 
transcriptional regulation
|
Hexokinase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270266 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31257027 |
BACH1 activates transcription of Hexokinase 2 and Gapdh and increases glucose uptake, glycolysis rates, and lactate secretion, thereby stimulating glycolysis-dependent metastasis of mouse and human lung cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Hexokinase | down-regulates quantity
chemical modification
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266459 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycolysis and Gluconeogenesis |
| + |
USF1 | up-regulates quantity by expression
transcriptional regulation
|
Hexokinase |
0.294 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270263 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 9677331 |
Cotransfection of an expression plasmid encoding USF1 into HepG2 hepatoma cells resulted in the activation of the glucokinase promoter, dependent on the integrity of the P2 element |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267797 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 9677331 |
Cotransfection of an expression plasmid encoding USF1 into HepG2 hepatoma cells resulted in the activation of the glucokinase promoter, dependent on the integrity of the P2 element |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
Hexokinase | up-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266449 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycolysis and Gluconeogenesis |
| + |
AKT | up-regulates activity
phosphorylation
|
Hexokinase |
0.498 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267577 |
|
|
Homo sapiens |
Cardiomyocyte Cell Line |
| pmid |
sentence |
| 25323588 |
Earlier studies found that expression of active Akt increases mitochondrial HK activity and the anti-apoptotic effect of Akt required mitoHK |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
glucose | up-regulates quantity by stabilization
|
Hexokinase |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270265 |
|
|
Homo sapiens |
ES-2 Cell |
| pmid |
sentence |
| 26323688 |
Consistently, treatment of cells with 2-deoxy-d-glucose (2DG), which completely inhibits glucose metabolism, leads to HK2 degradation and cell death in combination with C43 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP53 | down-regulates quantity by repression
transcriptional regulation
|
Hexokinase |
0.424 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270272 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
P53 regulates basal expression of AIF and SCO2 and facilitates oxidative phosphorylation. The expression of GLUT1, GLUT4, and HK2 is negatively regulated by p53, whereas TIGAR expression is induced by p53. The net result of p53-mediated regulation of these glycolytic enzymes is the suppression of glycolysis. In addition, p53 directly binds and inhibits G6PD activity and downregulates the pentose phosphate pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
HIF-1 complex | up-regulates quantity
transcriptional regulation
|
Hexokinase |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267494 |
|
|
Homo sapiens |
Burkitt Lymphoma Cell Line |
| pmid |
sentence |
| 17785433 |
Here, using the P493-6 Burkitt's lymphoma model with an inducible MYC, we demonstrate that HIF-1 cooperates with dysregulated c-Myc to promote glycolysis by induction of hexokinase 2, which catalyzes the first step of glycolysis, and pyruvate dehydrogenase kinase 1, which inactivates pyruvate dehydrogenase and diminishes mitochondrial respiration |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
PDX1 | up-regulates quantity by expression
transcriptional regulation
|
Hexokinase |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270264 |
|
|
Homo sapiens |
HIT-T15 Cell |
| pmid |
sentence |
| 8866550 |
The glycolytic enzyme glucokinase plays a primary role in the glucose-responsive secretion of insulin, and defects of this enzyme can cause NIDDM. As a step toward understanding the molecular basis of glucokinase (GK) gene regulation, we assessed the structure and regulation of the human GK gene beta-cell-type promoter. The results of reporter gene analyses using HIT-T15 cells revealed that the gene promoter was comprised of multiple cis-acting elements, including two primarily important cis-motifs: a palindrome structure, hPal-1, and the insulin gene cis-motif A element-like hUPE3. While both elements were bound specifically by nuclear proteins, it was the homeodomain-containing transcription factor insulin promoter factor 1 (IPF1)/STF-1/PDX-1 that bound to the hUPE3 site: IPF1, when expressed in CHO-K1 cells, became bound to the hUPE3 site and activated transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267798 |
|
|
Homo sapiens |
HIT-T15 Cell |
| pmid |
sentence |
| 8866550 |
The glycolytic enzyme glucokinase plays a primary role in the glucose-responsive secretion of insulin, and defects of this enzyme can cause NIDDM. As a step toward understanding the molecular basis of glucokinase (GK) gene regulation, we assessed the structure and regulation of the human GK gene beta-cell-type promoter. The results of reporter gene analyses using HIT-T15 cells revealed that the gene promoter was comprised of multiple cis-acting elements, including two primarily important cis-motifs: a palindrome structure, hPal-1, and the insulin gene cis-motif A element-like hUPE3. While both elements were bound specifically by nuclear proteins, it was the homeodomain-containing transcription factor insulin promoter factor 1 (IPF1)/STF-1/PDX-1 that bound to the hUPE3 site: IPF1, when expressed in CHO-K1 cells, became bound to the hUPE3 site and activated transcription. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
Hexokinase | down-regulates activity 
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270309 |
|
|
Mus musculus |
Fibroblast |
| pmid |
sentence |
| 16892090 |
HK II via its mitochondrial location also suppresses the death of cancer cells, thus increasing their possibility for metastasis and the ultimate death of the human host |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
HIF-1 complex | up-regulates quantity by expression
transcriptional regulation
|
Hexokinase |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267500 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
HIF-1 promotes glycolysis by transcriptionally upregulating GLUT1, GLUT3, HK1, and HK2. HIF-1 also suppresses oxidative phosphorylation by the upregulation of gene expression of BNIP3, BNIP3L, LDHA, and PDK1. In addition, HIF-1 can inhibit apoptosis by suppressing the expression of BID. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
Hexokinase | up-regulates
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267782 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18350175 |
The first step in metabolism of glucose (Glc) is usually phosphorylation, catalyzed by hexokinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity
transcriptional regulation
|
Hexokinase |
0.465 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270270 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17785433 |
Here, using the P493-6 Burkitt's lymphoma model with an inducible MYC, we demonstrate that HIF-1 cooperates with dysregulated c-Myc to promote glycolysis by induction of hexokinase 2, which catalyzes the first step of glycolysis, and pyruvate dehydrogenase kinase 1, which inactivates pyruvate dehydrogenase and diminishes mitochondrial respiration. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 | up-regulates activity
phosphorylation
|
Hexokinase |
0.498 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270267 |
|
|
Homo sapiens |
Nasopharyngeal Carcinoma Cell |
| pmid |
sentence |
| 31435020 |
K63-linked ubiquitination enhances the interaction between Akt and HK2 and eventually increases HK2 phosphorylation on Thr473 and mitochondrial localization |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Chaperone-mediated autophagy | down-regulates quantity by destabilization
|
Hexokinase |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270269 |
|
|
Homo sapiens |
ES-2 Cell |
| pmid |
sentence |
| 26323688 |
Our proteome analysis revealed that HK2 is a CMA substrate and that its degradation by CMA is regulated by glucose availability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Hexokinase