3.0
Summary
| Name |  OGTView Modifications |
| Full Name | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit |
| Synonyms | O-GlcNAc transferase subunit p110, O-linked N-acetylglucosamine transferase 110 kDa subunit, OGT |
| Primary ID | O15294 |
| Links |  -  -  |
| Type | protein |
| Relations | 10 |
| Function | Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:26678539, PubMed:23103939, PubMed:21240259, PubMed:21285374, PubMed:15361863). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:21285374). Probably by glycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing its ubiquitination (PubMed:26678539). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | OGT | up-regulates activity 
glycosylation
|
PYGL | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | OGT | down-regulates activity 
glycosylation
|
PFKL | 0.284 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | OGT | down-regulates activity
glycosylation
|
PFKM | 0.358 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | OGT | down-regulates activity
glycosylation
|
PFKP | 0.262 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | OGT | up-regulates activity
glycosylation
|
G6PD | 0.269 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TET3 | up-regulates
binding
|
OGT | 0.46 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | OGT | down-regulates activity
glycosylation
|
PFK | 0.358 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | OGT | form complex 
binding
|
NSL histone acetyltransferase | 0.533 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | OGT | up-regulates activity
glycosylation
|
TET1 | 0.457 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TET2 | up-regulates
binding
|
OGT | 0.461 |
| Publications: | 1 | Organism: | Homo Sapiens | |