3.0
Summary
| Name |  OGTView Modifications |
| Full Name | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit |
| Synonyms | O-GlcNAc transferase subunit p110, O-linked N-acetylglucosamine transferase 110 kDa subunit, OGT |
| Primary ID | O15294 |
| Links |  -  -  |
| Type | protein |
| Relations | 13 |
| Function | Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:26678539, PubMed:23103939, PubMed:21240259, PubMed:21285374, PubMed:15361863). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:21285374). Probably by glycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing its ubiquitination (PubMed:26678539). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | OGT | up-regulates activity 
glycosylation
|
YAP1 | 0.287 |
| Publications: | 1 | |||
| + | GSK3B | up-regulates activity
phosphorylation
|
OGT | 0.5 |
| Publications: | 2 | Organism: | Mus Musculus | |
| + | OGT | up-regulates activity
glycosylation
|
PYGL | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | OGT | down-regulates activity 
glycosylation
|
PFKL | 0.281 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | OGT | down-regulates activity
glycosylation
|
PFKM | 0.354 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | OGT | down-regulates activity
glycosylation
|
PFKP | 0.26 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | OGT | up-regulates activity
glycosylation
|
G6PD | 0.267 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TET3 | up-regulates
binding
|
OGT | 0.455 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | OGT | up-regulates activity
glycosylation
|
TET1 | 0.452 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | OGT | form complex 
binding
|
NSL histone acetyltransferase | 0.538 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | OGT | down-regulates activity
glycosylation
|
PFK | 0.354 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TET2 | up-regulates
binding
|
OGT | 0.456 |
| Publications: | 1 | Organism: | Homo Sapiens | |