Relation Results

Summary

Name PHLPP1
Full Name PH domain leucine-rich repeat-containing protein phosphatase 1
Synonyms Pleckstrin homology domain-containing family E member 1, PH domain-containing family E member 1, Suprachiasmatic nucleus circadian oscillatory protein, hSCOP | KIAA0606, PHLPP, PLEKHE1, SCOP
Primary ID O60346
Links - -
Type protein
Relations 20
Function Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members ...
View More

Viewer

Type: Score: Layout: SPV 
0.3570.3110.2740.640.7550.7550.6130.2520.3440.2990.583GSK3BPHLPP1CSNK1A1RAF1AKT3AKTAKT1AKT2PRKCAPRKCBSTK4RPS6KB1

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ GSK3Bdown-regulates img/direct_inhibition.png phosphorylation PHLPP1 0.357
Identifier Residue Sequence Organism Cell Line
SIGNOR-188330 Ser1359 VPRPHVQsVLLTPQD Homo sapiens
pmid sentence
In addition, we show that the beta-trcp-mediated degradation requires phosphorylation of phlpp1 by casein kinase i and glycogen synthase kinase 3beta (gsk-3beta), and activation of the phosphatidylinositol 3-kinase/akt pathway suppresses the degradation of phlpp1 by inhibiting the gsk-3beta activity.
Publications: 1 Organism: Homo Sapiens
+ GSK3Bdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PHLPP1 0.357
Identifier Residue Sequence Organism Cell Line
SIGNOR-276263 Ser1359 VPRPHVQsVLLTPQD Homo sapiens HEK-293T Cell
pmid sentence
We show that the beta-TrCP-mediated degradation requires phosphorylation of PHLPP1 by casein kinase I and glycogen synthase kinase 3beta (GSK-3beta), and activation of the phosphatidylinositol 3-kinase/Akt pathway suppresses the degradation of PHLPP1 by inhibiting the GSK-3beta activity. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-276264 Thr1363 HVQSVLLtPQDEFFI Homo sapiens HEK-293T Cell
pmid sentence
We show that the beta-TrCP-mediated degradation requires phosphorylation of PHLPP1 by casein kinase I and glycogen synthase kinase 3beta (GSK-3beta), and activation of the phosphatidylinositol 3-kinase/Akt pathway suppresses the degradation of PHLPP1 by inhibiting the GSK-3beta activity. 
Publications: 2 Organism: Homo Sapiens
+ CSNK1A1down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PHLPP1 0.311
Identifier Residue Sequence Organism Cell Line
SIGNOR-276261 Ser1359 VPRPHVQsVLLTPQD Homo sapiens HEK-293T Cell
pmid sentence
We show that the beta-TrCP-mediated degradation requires phosphorylation of PHLPP1 by casein kinase I and glycogen synthase kinase 3beta (GSK-3beta), and activation of the phosphatidylinositol 3-kinase/Akt pathway suppresses the degradation of PHLPP1 by inhibiting the GSK-3beta activity. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-276262 Thr1363 HVQSVLLtPQDEFFI Homo sapiens HEK-293T Cell
pmid sentence
We show that the beta-TrCP-mediated degradation requires phosphorylation of PHLPP1 by casein kinase I and glycogen synthase kinase 3beta (GSK-3beta), and activation of the phosphatidylinositol 3-kinase/Akt pathway suppresses the degradation of PHLPP1 by inhibiting the GSK-3beta activity. 
Publications: 2 Organism: Homo Sapiens
+ PHLPP1down-regulates activity img/direct_inhibition.png dephosphorylation RAF1 0.274
Identifier Residue Sequence Organism Cell Line
SIGNOR-237449 Ser338 RPRGQRDsSYYWEIE Mus musculus
pmid sentence
PHLPP1 and PHLPP2 dephosphorylate RAF1 to reduce its signaling, increase the invasive and migratory activities of CRC cells, and activate the epithelial-mesenchymal transition. In Apc(Min) mice, loss of PHLPP1 promotes tumor progression.
Publications: 1 Organism: Mus Musculus
+ PHLPP1down-regulates activity img/direct_inhibition.png dephosphorylation AKT3 0.64
Identifier Residue Sequence Organism Cell Line
SIGNOR-248330 Ser472 RPHFPQFsYSASGRE Homo sapiens Chronic Myeloid Leukemia Cell
pmid sentence
The Abl kinase inhibitors and depletion of Bcr-Abl induced the expression of PHLPP1 and PHLPP2, which dephosphorylated Ser-473 on Akt1, -2, and -3, resulting in inhibited proliferation of CML cells.|Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells.
Publications: 1 Organism: Homo Sapiens
+ PHLPP1down-regulates img/direct_inhibition.png dephosphorylation AKT 0.755
Identifier Residue Sequence Organism Cell Line
SIGNOR-135005 Ser473 RPHFPQFsYSASGTA Homo sapiens Glioblastoma Cell
pmid sentence
Here, we identify a protein_ phosphatase, ph domain leucine-rich repeat protein_ phosphatase_ (phlpp), that specifically_ dephosphorylates_ the hydrophobic motif of_ akt_ (ser473 in akt1), triggering_ apoptosis_ and suppressing_ tumor_ growth.
Publications: 1 Organism: Homo Sapiens
+ PHLPP1down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.755
Identifier Residue Sequence Organism Cell Line
SIGNOR-248327 Ser473 RPHFPQFsYSASGTA Homo sapiens Chronic Myeloid Leukemia Cell
pmid sentence
The Abl kinase inhibitors and depletion of Bcr-Abl induced the expression of PHLPP1 and PHLPP2, which dephosphorylated Ser-473 on Akt1, -2, and -3, resulting in inhibited proliferation of CML cells.|Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells.
Publications: 1 Organism: Homo Sapiens
+ PHLPP1down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.755
Identifier Residue Sequence Organism Cell Line
SIGNOR-252601 Ser473 RPHFPQFsYSASGTA Homo sapiens Glioblastoma Cell
pmid sentence
Here, we identify a protein_ phosphatase, ph domain leucine-rich repeat protein_ phosphatase_ (phlpp), that specifically_ dephosphorylates_ the hydrophobic motif of_ akt_ (ser473 in akt1), triggering_ apoptosis_ and suppressing_ tumor_ growth.
Publications: 1 Organism: Homo Sapiens
+ PHLPP1down-regulates activity img/direct_inhibition.png dephosphorylation AKT2 0.613
Identifier Residue Sequence Organism Cell Line
SIGNOR-248328 Ser474 RTHFPQFsYSASIRE Homo sapiens Chronic Myeloid Leukemia Cell
pmid sentence
The Abl kinase inhibitors and depletion of Bcr-Abl induced the expression of PHLPP1 and PHLPP2, which dephosphorylated Ser-473 on Akt1, -2, and -3, resulting in inhibited proliferation of CML cells.|Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells.
Publications: 1 Organism: Homo Sapiens
+ PHLPP1down-regulates quantity img/direct_inhibition.png dephosphorylation PRKCA 0.252
Identifier Residue Sequence Organism Cell Line
SIGNOR-237043 Ser657 QSDFEGFsYVNPQFV Homo sapiens Kidney Cell Line
pmid sentence
In addition, knockdown of PHLPP expression reduces the rate of phorbol ester-triggered dephosphorylation of the hydrophobic motif, but not turn motif, of PKC alpha
Publications: 1 Organism: Homo Sapiens
+ PHLPP1down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation PRKCB 0.344
Identifier Residue Sequence Organism Cell Line
SIGNOR-248326 Ser661 QNEFAGFsYTNPEFV Homo sapiens
pmid sentence
These data reveal that PHLPP controls the cellular levels of PKC by specifically dephosphorylating the hydrophobic motif, thus destabilizing the enzyme and promoting its degradation.|n contrast, results from siRNA depletion and overexpression experiments indicate that the hydrophobic motif site (Ser660) is regulated by PHLPP isoforms,
Publications: 1 Organism: Homo Sapiens
+ PHLPP1down-regulates quantity img/direct_inhibition.png dephosphorylation PRKCB 0.344
Identifier Residue Sequence Organism Cell Line
SIGNOR-237047 Ser661 QNEFAGFsYTNPEFV Homo sapiens Kidney Cell Line
pmid sentence
Here we show that the two PHLPP isoforms, PHLPP1 and PHLPP2, also dephosphorylate the hydrophobic motif on PKC betaII, an event that shunts PKC to the detergent-insoluble fraction, effectively terminating its life cycle
Publications: 1 Organism: Homo Sapiens
+ PHLPP1up-regulates activity img/direct-activation.png dephosphorylation STK4 0.299
Identifier Residue Sequence Organism Cell Line
SIGNOR-248329 Thr387 TMKRRDEtMQPAKPS Homo sapiens
pmid sentence
PHLPPs dephosphorylate Mst1 on the T387 inhibitory site, which activate Mst1 and its downstream effectors p38 and JNK to induce apoptosis.
Publications: 1 Organism: Homo Sapiens
+ PHLPP1down-regulates activity img/direct_inhibition.png dephosphorylation RPS6KB1 0.583
Identifier Residue Sequence Organism Cell Line
SIGNOR-237454 Thr390 DSKFTRQtPVDSPDD Homo sapiens
pmid sentence
Here we report the identification of ribosomal protein S6 kinase 1 (S6K1) as a novel substrate of PHLPP.
Publications: 1 Organism: Homo Sapiens
+ PHLPP1down-regulates activity img/direct_inhibition.png dephosphorylation AKT 0.755
Identifier Residue Sequence Organism Cell Line
SIGNOR-248331 Homo sapiens Chronic Myeloid Leukemia Cell
pmid sentence
The Abl kinase inhibitors and depletion of Bcr-Abl induced the expression of PHLPP1 and PHLPP2, which dephosphorylated Ser-473 on Akt1, -2, and -3, resulting in inhibited proliferation of CML cells.|Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells.
Publications: 1 Organism: Homo Sapiens
+ PHLPP1up-regulates img/direct-activation.png binding STK4 0.299
Identifier Residue Sequence Organism Cell Line
SIGNOR-201262 Homo sapiens
pmid sentence
Here, we report that phlpp1 is a binding protein for mst1 and it modulates the hippo pathway by dephosphorylating mst1 at the inhibitory thr(387) of mst1.
Publications: 1 Organism: Homo Sapiens
+ PHLPP1 img/unknown.png dephosphorylation AKT2 0.613
Identifier Residue Sequence Organism Cell Line
SIGNOR-135008 Homo sapiens Glioblastoma Cell
pmid sentence
These data are consistent with phlpp terminating akt signaling by directly dephosphorylating and inactivating akt / phlpp1 specifically modulates the phosphorylation of hdm2 and gsk-3alpha through akt2, whereas phlpp2 specifically modulates the phosphorylation of p27 through akt3
Publications: 1 Organism: Homo Sapiens
+ PHLPP1down-regulates img/direct_inhibition.png dephosphorylation AKT2 0.613
Identifier Residue Sequence Organism Cell Line
SIGNOR-153935 Homo sapiens
pmid sentence
These data are consistent with phlpp terminating akt signaling by directly dephosphorylating and inactivating akt / phlpp1 specifically modulates the phosphorylation of hdm2 and gsk-3alpha through akt2, whereas phlpp2 specifically modulates the phosphorylation of p27 through akt3
Publications: 1 Organism: Homo Sapiens
a simple tooltip