| + |
GSK3B | down-regulates 
phosphorylation
|
PHLPP1 |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188330 |
Ser1359 |
VPRPHVQsVLLTPQD |
Homo sapiens |
|
| pmid |
sentence |
| 19797085 |
In addition, we show that the beta-trcp-mediated degradation requires phosphorylation of phlpp1 by casein kinase i and glycogen synthase kinase 3beta (gsk-3beta), and activation of the phosphatidylinositol 3-kinase/akt pathway suppresses the degradation of phlpp1 by inhibiting the gsk-3beta activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B | down-regulates quantity by destabilization
phosphorylation
|
PHLPP1 |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276263 |
Ser1359 |
VPRPHVQsVLLTPQD |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 19797085 |
We show that the beta-TrCP-mediated degradation requires phosphorylation of PHLPP1 by casein kinase I and glycogen synthase kinase 3beta (GSK-3beta), and activation of the phosphatidylinositol 3-kinase/Akt pathway suppresses the degradation of PHLPP1 by inhibiting the GSK-3beta activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276264 |
Thr1363 |
HVQSVLLtPQDEFFI |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 19797085 |
We show that the beta-TrCP-mediated degradation requires phosphorylation of PHLPP1 by casein kinase I and glycogen synthase kinase 3beta (GSK-3beta), and activation of the phosphatidylinositol 3-kinase/Akt pathway suppresses the degradation of PHLPP1 by inhibiting the GSK-3beta activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CSNK1A1 | down-regulates quantity by destabilization
phosphorylation
|
PHLPP1 |
0.313 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276261 |
Ser1359 |
VPRPHVQsVLLTPQD |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 19797085 |
We show that the beta-TrCP-mediated degradation requires phosphorylation of PHLPP1 by casein kinase I and glycogen synthase kinase 3beta (GSK-3beta), and activation of the phosphatidylinositol 3-kinase/Akt pathway suppresses the degradation of PHLPP1 by inhibiting the GSK-3beta activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276262 |
Thr1363 |
HVQSVLLtPQDEFFI |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 19797085 |
We show that the beta-TrCP-mediated degradation requires phosphorylation of PHLPP1 by casein kinase I and glycogen synthase kinase 3beta (GSK-3beta), and activation of the phosphatidylinositol 3-kinase/Akt pathway suppresses the degradation of PHLPP1 by inhibiting the GSK-3beta activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PHLPP1 | down-regulates activity
dephosphorylation
|
RAF1 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-237449 |
Ser338 |
RPRGQRDsSYYWEIE |
Mus musculus |
|
| pmid |
sentence |
| 24530606 |
PHLPP1 and PHLPP2 dephosphorylate RAF1 to reduce its signaling, increase the invasive and migratory activities of CRC cells, and activate the epithelial-mesenchymal transition. In Apc(Min) mice, loss of PHLPP1 promotes tumor progression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PHLPP1 | down-regulates activity
dephosphorylation
|
AKT3 |
0.635 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248330 |
Ser472 |
RPHFPQFsYSASGRE |
Homo sapiens |
Chronic Myeloid Leukemia Cell |
| pmid |
sentence |
| 19261608 |
The Abl kinase inhibitors and depletion of Bcr-Abl induced the expression of PHLPP1 and PHLPP2, which dephosphorylated Ser-473 on Akt1, -2, and -3, resulting in inhibited proliferation of CML cells.|Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHLPP1 | down-regulates activity
dephosphorylation
|
AKT1 |
0.752 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248327 |
Ser473 |
RPHFPQFsYSASGTA |
Homo sapiens |
Chronic Myeloid Leukemia Cell |
| pmid |
sentence |
| 19261608 |
The Abl kinase inhibitors and depletion of Bcr-Abl induced the expression of PHLPP1 and PHLPP2, which dephosphorylated Ser-473 on Akt1, -2, and -3, resulting in inhibited proliferation of CML cells.|Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHLPP1 | down-regulates
dephosphorylation
|
AKT |
0.752 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135005 |
Ser473 |
RPHFPQFsYSASGTA |
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 15808505 |
Here, we identify a protein_ phosphatase, ph domain leucine-rich repeat protein_ phosphatase_ (phlpp), that specifically_ dephosphorylates_ the hydrophobic motif of_ akt_ (ser473 in akt1), triggering_ apoptosis_ and suppressing_ tumor_ growth. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHLPP1 | down-regulates
dephosphorylation
|
AKT1 |
0.752 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252601 |
Ser473 |
RPHFPQFsYSASGTA |
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 15808505 |
Here, we identify a protein_ phosphatase, ph domain leucine-rich repeat protein_ phosphatase_ (phlpp), that specifically_ dephosphorylates_ the hydrophobic motif of_ akt_ (ser473 in akt1), triggering_ apoptosis_ and suppressing_ tumor_ growth. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHLPP1 | down-regulates activity
dephosphorylation
|
AKT2 |
0.607 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248328 |
Ser474 |
RTHFPQFsYSASIRE |
Homo sapiens |
Chronic Myeloid Leukemia Cell |
| pmid |
sentence |
| 19261608 |
The Abl kinase inhibitors and depletion of Bcr-Abl induced the expression of PHLPP1 and PHLPP2, which dephosphorylated Ser-473 on Akt1, -2, and -3, resulting in inhibited proliferation of CML cells.|Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHLPP1 | down-regulates quantity
dephosphorylation
|
PRKCA |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-237043 |
Ser657 |
QSDFEGFsYVNPQFV |
Homo sapiens |
Kidney Cell Line |
| pmid |
sentence |
| 18162466 |
In addition, knockdown of PHLPP expression reduces the rate of phorbol ester-triggered dephosphorylation of the hydrophobic motif, but not turn motif, of PKC alpha |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHLPP1 | down-regulates quantity by destabilization
dephosphorylation
|
PRKCB |
0.347 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248326 |
Ser661 |
QNEFAGFsYTNPEFV |
Homo sapiens |
|
| pmid |
sentence |
| 18162466 |
These data reveal that PHLPP controls the cellular levels of PKC by specifically dephosphorylating the hydrophobic motif, thus destabilizing the enzyme and promoting its degradation.|n contrast, results from siRNA depletion and overexpression experiments indicate that the hydrophobic motif site (Ser660) is regulated by PHLPP isoforms, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHLPP1 | down-regulates quantity
dephosphorylation
|
PRKCB |
0.347 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-237047 |
Ser661 |
QNEFAGFsYTNPEFV |
Homo sapiens |
Kidney Cell Line |
| pmid |
sentence |
| 18162466 |
Here we show that the two PHLPP isoforms, PHLPP1 and PHLPP2, also dephosphorylate the hydrophobic motif on PKC betaII, an event that shunts PKC to the detergent-insoluble fraction, effectively terminating its life cycle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHLPP1 | up-regulates activity 
dephosphorylation
|
STK4 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248329 |
Thr387 |
TMKRRDEtMQPAKPS |
Homo sapiens |
|
| pmid |
sentence |
| 20513427 |
PHLPPs dephosphorylate Mst1 on the T387 inhibitory site, which activate Mst1 and its downstream effectors p38 and JNK to induce apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHLPP1 | down-regulates activity
dephosphorylation
|
RPS6KB1 |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-237454 |
Thr390 |
DSKFTRQtPVDSPDD |
Homo sapiens |
|
| pmid |
sentence |
| 21986499 |
Here we report the identification of ribosomal protein S6 kinase 1 (S6K1) as a novel substrate of PHLPP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHLPP1 | down-regulates activity
dephosphorylation
|
AKT |
0.752 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248331 |
|
|
Homo sapiens |
Chronic Myeloid Leukemia Cell |
| pmid |
sentence |
| 19261608 |
The Abl kinase inhibitors and depletion of Bcr-Abl induced the expression of PHLPP1 and PHLPP2, which dephosphorylated Ser-473 on Akt1, -2, and -3, resulting in inhibited proliferation of CML cells.|Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHLPP1 | down-regulates
dephosphorylation
|
AKT2 |
0.607 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153935 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17386267 |
These data are consistent with phlpp terminating akt signaling by directly dephosphorylating and inactivating akt / phlpp1 specifically modulates the phosphorylation of hdm2 and gsk-3alpha through akt2, whereas phlpp2 specifically modulates the phosphorylation of p27 through akt3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHLPP1 |
dephosphorylation
|
AKT2 |
0.607 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135008 |
|
|
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 15808505 |
These data are consistent with phlpp terminating akt signaling by directly dephosphorylating and inactivating akt / phlpp1 specifically modulates the phosphorylation of hdm2 and gsk-3alpha through akt2, whereas phlpp2 specifically modulates the phosphorylation of p27 through akt3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHLPP1 | up-regulates
binding
|
STK4 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201262 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Here, we report that phlpp1 is a binding protein for mst1 and it modulates the hippo pathway by dephosphorylating mst1 at the inhibitory thr(387) of mst1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PHLPP1
- 
- 