Summary

Name NR1I2
Full Name Nuclear receptor subfamily 1 group I member 2
Synonyms Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, Pregnane X receptor, Steroid and xenobiotic receptor, SXR | PXR
Primary ID O75469
Links - -
Type protein
Relations 5
Function Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation UGT1A1 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCB1 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP3A4 0.90
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NR1I2 0.38
Publications: 1 Organism: Homo Sapiens