| + |
UVB radiation | up-regulates 
|
IL1A |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252384 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9767234 |
UVB can stimulate the synthesis of IL-1, TNF-a and ET-1, and other cytokines by keratinocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1A | up-regulates quantity by expression
transcriptional regulation
|
TNF |
0.507 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252209 |
|
|
Homo sapiens |
Keratinocyte |
| pmid |
sentence |
| 19005488 |
UVB and proinflammatory cytokines synergistically activate TNF-alpha production in keratinocytes through enhanced gene transcription. UVB and IL-1alpha treatment synergistically enhanced TNF-alpha secretion and mRNA levels in human keratinocytes, similar to the findings reported previously in human fibroblasts. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1A | down-regulates quantity by repression 
transcriptional regulation
|
FBN1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251890 |
|
|
Homo sapiens |
Fibroblast |
| pmid |
sentence |
| 9036927 |
UVB irradiation (50 mJ) of cultured skin fibroblasts suppressed fibrillin mRNA by 50%, consistent with a direct effect of radiation. UVB irradiation (50 mJ) of cultured skin fibroblasts suppressed fibrillin mRNA by 50%, consistent with a direct effect of radiation. Addition to the cultured fibroblasts of several cytokines upregulated by UVB showed that IL-1alpha had no effect on fibrillin mRNA in unirradiated cells, but in irradiated cells, this cytokine enhanced the suppression of fibrillin mRNA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1A | up-regulates quantity by expression
transcriptional regulation
|
MC1R |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252387 |
|
|
Homo sapiens |
Melanocyte |
| pmid |
sentence |
| 9767234 |
MSH receptor (MSH-R) binding activity was upregulated by UVB, IL-1alpha, -1beta and ET-1, but was downregulated by TNF-alpha.Northern blotanalysis showed that MC1-R mRNA expression was induced 24 h after UVB irradiation in a dose-dependent manner, and that 24-h treatment with ET-1 also induced an expression of MC1-R mRNA,whereas TNF-a downregulated the expression. In addition, IL-1a and -1b have a small but real inductiveeffect on MC1-R mRNA expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1A | up-regulates
|
Inflammation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171873 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21304099 |
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling |
| + |
IL1A | up-regulates quantity by expression
transcriptional regulation
|
SERPINA3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254807 |
|
|
Homo sapiens |
Astrocyte Cell Line |
| pmid |
sentence |
| 11027208 |
We characterize a molecular mechanism responsible for both IL-1 and TNF-induced expression of ACT gene in astrocytes. We identify the 5' distal IL-1/TNF-responsive enhancer of the ACT gene located 13 kb upstream of the transcription start site. This 413-bp-long enhancer contains three elements, two of which bind nuclear factor kB (NF-kB) and one that binds activating protein 1 (AP-1). All of these elements contribute to the full responsiveness of the ACT gene to both cytokines, as determined by deletion and mutational analysis. The 5' NF-kB high-affinity binding site and AP-1 element contribute most to the enhancement of gene transcription in response to TNF and IL-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1A | up-regulates activity 
binding
|
IL1R1 |
0.759 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-35077 |
|
|
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 7964161 |
Interleukin-1 receptor (il-1r) is a cytokine receptor which binds interleukin 1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56718 |
|
|
Homo sapiens |
Brain Cancer Cell |
| pmid |
sentence |
| 9565970 |
Il-1ri is responsible for il-1 signaling |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling |
3.0
IL1A
- 
- 