| + |
MMP1 | down-regulates quantity by destabilization 
cleavage
|
COL1A1 |
0.387 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272336 |
Gly776 |
IGPPGPAgAPGDKGE |
in vitro |
|
| pmid |
sentence |
| 17318226 |
In vitro, MMP1 initiates degradation of native fibrillar collagens, crucial components of vertebrate extracellular matrix (ECM), by cleaving the peptide bond between Gly775–Ile776 or Gly775–Lys776 in native type I, II or III collagen molecules3,4. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
COL1A1 | up-regulates activity 
binding
|
DDR2 |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272342 |
|
|
Homo sapiens |
HT-1080 Cell |
| pmid |
sentence |
| 17318226 |
The Discoidin Domain Receptors (DDRs) constitute a unique set of receptor tyrosine kinases that signal in response to collagen.|Consistent with this view128, we showed that ectopic expression of DDR1b or DDR2 in HT1080 cells elicited a potent growth inhibitory effect only when the cells were cultured on 2D or 3D COL1 matrices, in agreement with previous studies in melanoma48, breast cancer76,78, and lung cancer cells74,75. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COLGALT1 | up-regulates activity
glycosylation
|
COL1A1 |
0.384 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261152 |
|
|
in vitro |
|
| pmid |
sentence |
| 19075007 |
Recombinant GLT25D1 and GLT25D2 enzymes showed a strong galactosyltransferase activity toward various types of collagen and toward the serum mannose-binding lectin MBL, which contains a collagen domain. Amino acid analysis of the products of GLT25D1 and GLT25D2 reactions confirmed the transfer of galactose to hydroxylysine residues. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
COL1A1 | up-regulates activity
binding
|
A2/b1 integrin |
0.623 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272346 |
|
|
|
|
| pmid |
sentence |
| 35267698 |
Integrins constitute a major group of receptors for extracellular matrix components, including collagens.|Among the four types, the signaling mechanism of α1β1 and α2β1 integrins has especially been reported. These integrins bind to both collagen types I and IV; however, their affinities differ: α1β1 has a higher affinity for collagen type IV, while α2β1 preferentially binds to collagen type I [13,23]. |
|
| Publications: |
1 |
| + |
RUNX2 | up-regulates quantity by expression 
transcriptional regulation
|
COL1A1 |
0.465 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107163 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331591 |
In addition to osteocalcin, cbfa1 regulates expression of several other genes that are activated during osteoblast differentiation, including alkaline phosphatase, a1 and a2 collagen, osteopontin and osteoprotegerin ligand. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL1A1 | up-regulates
binding
|
DDR1 |
0.343 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-58779 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9659900 |
We report that the collagens serve as ligands for the previously orphan family of discoidin domain-containing receptor-like tyrosine kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL1A1 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254662 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21949456 |
Collagen is the major structural protein in skeletal muscle ECM;...Several studies suggest that perimysial collagen is predominantly type I |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates quantity by expression
transcriptional regulation
|
COL1A1 |
0.277 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-192796 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
(tak1) and tak1 binding protein 1 (tab1) play a pivotal role as upstream sig-nal transducers by activating the mkk3-p38 mapk signaling cascade that leads to the induction of type i collagen expression by tgf-beta1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL1A1 | up-regulates activity
binding
|
A1/b1 integrin |
0.55 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253247 |
|
|
Homo sapiens |
K-562 Cell |
| pmid |
sentence |
| 12123670 |
We have developed a cell-free assay for binding of solubilized beta1 integrins to their physiologically relevant ligands using an electrochemiluminescent detection method|Binding was clearly optimal for the presumed physiological ligands, i.e., collagen IV for a1b1, collagen I for a2b1, VCAM-Ig for a4b1, fibronectin (the 120-kDa cell attachment fragment was used) for a5b1, and laminin for a6b1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL1A1 | up-regulates activity
binding
|
A11/b1 integrin |
0.565 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253345 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 12496264 |
Modeling of the alpha I domain-collagen peptide complexes could partially explain the observed preference of different I domains for certain GFOGER sequence variations. In summary, our data indicate that the GFOGER sequence in fibrillar collagens is a common recognition motif used by alpha(1)beta(1), alpha(2)beta(1), and also alpha(11)beta(1) integrins. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
COL1A1 | up-regulates
binding
|
A2/b1 integrin |
0.623 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-31787 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7688313 |
Both a2b1- and a1b1- inegrins are implicated in chondrocyte adhesion to native collagene i and ii |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMOC1 | up-regulates quantity by expression
transcriptional regulation
|
COL1A1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260402 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20359165 |
The expression of several osteoblast differentiation markers (ALP, COL1, OPN, ON, BSP and OC) was higher in SMOC1-overexpressing cells than in emptyvector-expressing cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL1A1 | up-regulates activity
binding
|
DDR1 |
0.343 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272340 |
|
|
Homo sapiens |
HT-1080 Cell |
| pmid |
sentence |
| 17318226 |
The Discoidin Domain Receptors (DDRs) constitute a unique set of receptor tyrosine kinases that signal in response to collagen.|Consistent with this view128, we showed that ectopic expression of DDR1b or DDR2 in HT1080 cells elicited a potent growth inhibitory effect only when the cells were cultured on 2D or 3D COL1 matrices, in agreement with previous studies in melanoma48, breast cancer76,78, and lung cancer cells74,75. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COLGALT2 | up-regulates activity
glycosylation
|
COL1A1 |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261156 |
|
|
in vitro |
|
| pmid |
sentence |
| 19075007 |
Recombinant GLT25D1 and GLT25D2 enzymes showed a strong galactosyltransferase activity toward various types of collagen and toward the serum mannose-binding lectin MBL, which contains a collagen domain. Amino acid analysis of the products of GLT25D1 and GLT25D2 reactions confirmed the transfer of galactose to hydroxylysine residues. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
COL1A1 |
0.499 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277678 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35816922 |
COL1A1 expression is regulated by upstream genes and the binding of regulatory elements at multiple binding sites upstream of its promoter. During cancer progression, CAFs reorganize and cross-link COL1A1, which accumulates and stiffens in the tumor stroma [12], [18]. This process may involve fibrogenic factors, especially transforming growth factor-beta (TGF-β1). Indeed, a TGF-β1 response sequence was identified 174 nucleotides upstream of the COL1A1 transcription start site, and was shown to up-regulate COL1A1 promoter activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Pancreas |
| + |
BMP1 | up-regulates activity
cleavage
|
COL1A1 |
0.668 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256342 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 11283002 |
BMP-1myc Expressed in COS-7 Cells Exhibits Procollagen C-proteinase Activity. Bone morphogenetic protein (BMP)-1, which belongs to the tolloid subgroup of astacin-like zinc metalloproteinases, cleaves the C-propeptides of procollagen at the physiologic site and is, therefore, a procollagen C-proteinase (PCP). Cleavage occurs between a specific alanine or glycine residue (depending on the procollagen chain) and an invariant aspartic acid residue in each of the three chains of procollagen. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
3.0
COL1A1
- 
- 