Summary

Name HMGCR
Full Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Synonyms HMG-CoA reductase
Primary ID P04035
Links - -
Type protein
Relations 8
Inhibitors lovastatin; simvastatin; Clinofibrate; pravastatin
Function Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:2991281, PubMed:21357570, PubMed:6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation HMGCR 0.338
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HMGCR 0.8
Publications: 2 Organism: In Vitro
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HMGCR 0.516
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
+ down-regulates activity img/direct_inhibition.png chemical inhibition HMGCR 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition HMGCR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HMGCR 0.8
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination HMGCR 0.583
Publications: 1 Organism: Mus Musculus