Summary

Name VWF
Full Name von Willebrand factor
Synonyms vWF | F8VWF
Primary ID P04275
Links - -
Type protein
Relations 7
Function Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation VWF 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation VWF 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation VWF 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation VWF 0.22
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding F8 0.48
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png cleavage VWF 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding VWF 0.14
Publications: 1 Organism: Homo Sapiens