Relation Results

Summary

Name PGR
Full Name Progesterone receptor
Synonyms PR, Nuclear receptor subfamily 3 group C member 3 | NR3C3
Primary ID P06401
Links - -
Type protein
Relations 19
Function The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differenti ...
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Type: Score: Layout: SPV 
0.4490.550.5950.2790.3560.80.20.6140.20.260.6140.6780.598CDK2PGRMAPK3MAPK1GSK3BCSNK2A1tiboloneGbetaESR1ERK1/2KLK4NCOA1NCOR2

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CDK2 img/unknown.png phosphorylation PGR 0.449
Identifier Residue Sequence Organism Cell Line
SIGNOR-84980 Ser20 HVAGGPPsPEVGSPL Homo sapiens
pmid sentence
In vitro phosphorylation of pr with cdk2 has revealed five additional in vitro cdk2 phosphorylation sites: ser(25), ser(213), thr(430), ser(554), and ser(676).
Identifier Residue Sequence Organism Cell Line
SIGNOR-84984 Ser213 SGAPVKPsPQAAAVE Homo sapiens
pmid sentence
In vitro phosphorylation of pr with cdk2 has revealed five additional in vitro cdk2 phosphorylation sites: ser(25), ser(213), thr(430), ser(554), and ser(676).
Identifier Residue Sequence Organism Cell Line
SIGNOR-84988 Ser25 PPSPEVGsPLLCRPA Homo sapiens
pmid sentence
In vitro phosphorylation of pr with cdk2 has revealed five additional in vitro cdk2 phosphorylation sites: ser(25), ser(213), thr(430), ser(554), and ser(676).
Identifier Residue Sequence Organism Cell Line
SIGNOR-84992 Ser554 PDSEASQsPQYSFES Homo sapiens
pmid sentence
In vitro phosphorylation of pr with cdk2 has revealed five additional in vitro cdk2 phosphorylation sites: ser(25), ser(213), thr(430), ser(554), and ser(676).
Identifier Residue Sequence Organism Cell Line
SIGNOR-84996 Ser676 LSQRFTFsPGQDIQL Homo sapiens
pmid sentence
In vitro phosphorylation of pr with cdk2 has revealed five additional in vitro cdk2 phosphorylation sites: ser(25), ser(213), thr(430), ser(554), and ser(676).
Identifier Residue Sequence Organism Cell Line
SIGNOR-85000 Thr430 PPLPPRAtPSRPGEA Homo sapiens
pmid sentence
In vitro phosphorylation of pr with cdk2 has revealed five additional in vitro cdk2 phosphorylation sites: ser(25), ser(213), thr(430), ser(554), and ser(676).
Publications: 6 Organism: Homo Sapiens
+ MAPK3down-regulates img/direct_inhibition.png phosphorylation PGR 0.55
Identifier Residue Sequence Organism Cell Line
SIGNOR-74716 Ser294 APMAPGRsPLATTVM Homo sapiens Breast Cancer Cell
pmid sentence
Specifically, down-regulation of mature prs occurs by a mechanism in which ligand binding activates pr phosphorylation by mapks at a unique serine residue, which then targets the receptors for degradation.
Publications: 1 Organism: Homo Sapiens
+ MAPK1down-regulates img/direct_inhibition.png phosphorylation PGR 0.595
Identifier Residue Sequence Organism Cell Line
SIGNOR-74712 Ser294 APMAPGRsPLATTVM Homo sapiens Breast Cancer Cell
pmid sentence
Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26s proteasome
Publications: 1 Organism: Homo Sapiens
+ CDK2down-regulates img/direct_inhibition.png phosphorylation PGR 0.449
Identifier Residue Sequence Organism Cell Line
SIGNOR-74708 Ser294 APMAPGRsPLATTVM Homo sapiens Breast Cancer Cell
pmid sentence
Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26s proteasome
Publications: 1 Organism: Homo Sapiens
+ GSK3Bdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PGR 0.279
Identifier Residue Sequence Organism Cell Line
SIGNOR-276498 Ser554 PDSEASQsPQYSFES Homo sapiens
pmid sentence
Here, we have found that glycogen synthase kinase (GSK)-3β phosphorylation of progesterone receptor-A (PR-A) facilitates its ubiquitination. GSK-3β-mediated phosphorylation of serine 390 in PR-A regulates its subsequent ubiquitination and protein stability.
Publications: 1 Organism: Homo Sapiens
+ CSNK2A1 img/unknown.png phosphorylation PGR 0.356
Identifier Residue Sequence Organism Cell Line
SIGNOR-250926 Ser81 TQDQQSLsDVEGAYS in vitro
pmid sentence
Although human PR contains 11 potential CKII consensus sequences, CKII in vitro phosphorylated purified PR-B only at Ser81 suggesting that this may be an authentic site for CKII in vivo.
Publications: 1 Organism: In Vitro
+ tiboloneup-regulates activity img/direct-activation.png chemical activation PGR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-257822 Homo sapiens
pmid sentence
In this study, we have assessed the potential hormonal profile of tibolone and its primary metabolites on all human steroid receptors (PR, AR, GR, MR, ERα and ERβ) using HeLa or PC3 cells stably transfected with a given receptor and a luciferase reporter gene. We show that tibolone and its ∆ 4 -isomer predominantly bind and activate PR and AR whereas 3α and 3β-OH-tibolone predominantly bind and activate ERα (Table 1).
Publications: 1 Organism: Homo Sapiens
+ Gbetadown-regulates img/direct_inhibition.png phosphorylation PGR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270040 Homo sapiens Breast Cancer Cell
pmid sentence
Specifically, down-regulation of mature prs occurs by a mechanism in which ligand binding activates pr phosphorylation by mapks at a unique serine residue, which then targets the receptors for degradation.
Publications: 1 Organism: Homo Sapiens
+ ESR1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PGR 0.614
Identifier Residue Sequence Organism Cell Line
SIGNOR-82161 Homo sapiens
pmid sentence
We observed the transcriptional inhibition of the progesterone and glucocorticoid receptors when eralpha was cotransfected
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates img/direct_inhibition.png phosphorylation PGR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270157 Homo sapiens Breast Cancer Cell
pmid sentence
Specifically, down-regulation of mature prs occurs by a mechanism in which ligand binding activates pr phosphorylation by mapks at a unique serine residue, which then targets the receptors for degradation.
Publications: 1 Organism: Homo Sapiens
+ PGRup-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLK4 0.26
Identifier Residue Sequence Organism Cell Line
SIGNOR-254913 Homo sapiens T-47D Cell
pmid sentence
we have shown that K4.pPRE interacts directly with the PR to up-regulate KLK4 gene expression in T47D cells.
Publications: 1 Organism: Homo Sapiens
+ PGRup-regulates img/direct-activation.png binding ESR1 0.614
Identifier Residue Sequence Organism Cell Line
SIGNOR-98807 Homo sapiens Breast Cancer Cell
pmid sentence
Here we identify two domains of prb, erid-i and -ii, mediating a direct interaction with the ligand-binding domain of eralpha.
Publications: 1 Organism: Homo Sapiens
+ NCOA1up-regulates img/indirect-activation.png PGR 0.678
Identifier Residue Sequence Organism Cell Line
SIGNOR-70149 Homo sapiens
pmid sentence
Progesterone receptor (pr) functions as a transcription factor that modulates the transcription of target genes in response to progesterone and other signals. The transcriptional activity of pr requires the involvement of coactivators such as steroid receptor coactivator-1 (src-1).
Publications: 1 Organism: Homo Sapiens
+ NCOR2down-regulates img/direct_inhibition.png acetylation PGR 0.598
Identifier Residue Sequence Organism Cell Line
SIGNOR-101289 Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell
pmid sentence
In this study we assessed the effect of smrt and dax-1 on ar and pr activity in the presence of both agonists and partial antagonists. We show that smrt and dax-1 repress agonist-dependent activity of both receptors, and the mechanism of repression includes disruption of the receptor dimer interactions rather than recruitment of histone deacetylases.
Publications: 1 Organism: Homo Sapiens
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