Summary

Name RARB
Full Name Retinoic acid receptor beta
Synonyms RAR-beta, HBV-activated protein, Nuclear receptor subfamily 1 group B member 2, RAR-epsilon | HAP, NR1B2
Primary ID P10826
Links - -
Type protein
Relations 10
Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding RXRA 0.71
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRB 0.63
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RARB
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png unknown RARB 0.16
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RARB 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RARB
Publications: 1 Organism: Homo Sapiens
Tissue: Heart
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RARB 0.63
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding THRA 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RARB 0.71
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RARB 0.63
Publications: 1 Organism: Homo Sapiens