| + |
THRA | up-regulates 
binding
|
RARB |
0.39 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133243 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15650024 |
Ee report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Oxytocin signaling |
| + |
GATA6 | up-regulates quantity by expression 
|
RARB |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253154 |
|
|
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 24317510 |
Many GATA6-dependent genes lacked nearby binding sites but several strongly dependent, synexpressed and GATA6-bound genes encode TFs such as MYC, HES1, RARB and CDX2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARB | up-regulates
binding
|
THRA |
0.39 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133234 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15650024 |
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Oxytocin signaling |
| + |
THR | up-regulates
binding
|
RARB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270314 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15650024 |
Ee report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
adapalene | up-regulates activity
chemical activation
|
RARB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258487 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30836068 |
Adapalene, the third-generation synthetic retinoid,selectively bound to specific RAR, thus activating genes responsible forcellular differentiation. It showed greatest affinity for subtypes RARβindermalfibroblasts (Kd value 34 nM) and RARγin the epidermis (Kdvalue 130 nM) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Epidermis |
| + |
4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid | up-regulates activity
chemical activation
|
RARB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258035 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 19058965 |
Tazarotene and its analogue 8 are RAR-β,γ selective acetylenic retinoids, whereas analogue 9 is very active on the three subtypes. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
RARB | up-regulates
binding
|
RXRA |
0.666 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16519 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Retinoic acid Signaling |
| + |
RXRB | up-regulates quantity by expression
transcriptional regulation
|
RARB |
0.65 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16680 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARB | up-regulates quantity by expression
transcriptional regulation
|
OXT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268549 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 6153132 |
The human and rat OT promoters could be stimulated by the ligand-activated estrogen receptors ERalpha and ERbeta, the thyroid hormone receptor THRapha, and the retinoic acid receptors RARalpha and RARbeta in a variety of cells (3, 477, 478). However, it is important to note that these results were obtained from cotransfection experiments in cell lines, i.e., under nonphysiological circumstances. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Oxytocin signaling |
| + |
THR | up-regulates activity
binding
|
RARB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267780 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15650024 |
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
9-cis-retinoic acid | up-regulates activity
chemical activation
|
RARB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259235 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18321241 |
Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRA | up-regulates
binding
|
RARB |
0.666 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16668 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Retinoic acid Signaling |
| + |
all-trans-retinoic acid | up-regulates activity
chemical activation
|
RARB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256195 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17132853 |
The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are encoded by three distinct human genes, RXRalpha, RXRbeta, and RXRgamma. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258137 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 19058965 |
Tazarotene and its analogue 8 are RAR-β,γ selective acetylenic retinoids, whereas analogue 9 is very active on the three subtypes. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Chlorocebus Aethiops |
| Pathways: | Retinoic acid Signaling |
| + |
RARB | up-regulates
binding
|
RXRB |
0.65 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16581 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARB | up-regulates activity
binding
|
THR |
0.398 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267807 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15650024 |
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRB | up-regulates
binding
|
RARB |
0.65 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16677 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARB | up-regulates
binding
|
THR |
0.398 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270299 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15650024 |
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PBRM1 | up-regulates quantity by expression
transcriptional regulation
|
RARB |
0.43 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132378 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15601824 |
We found that baf180 deficiency leads to a decreased expression of select target genes, such as s100a13 and ra targets rar_2 and crabpii in heart tissues. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
tazarotene | up-regulates activity
chemical activation
|
RARB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258028 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 19058965 |
Tazarotene and its analogue 8 are RAR-β,γ selective acetylenic retinoids, whereas analogue 9 is very active on the three subtypes. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
3.0
RARB
- 
- 