| + |
WWP2 | down-regulates quantity 
ubiquitination
|
EGR2 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268849 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19651900 |
The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination|AIP2 interacts with and promotes ubiquitin-mediated degradation of EGR2, a zinc finger transcription factor that has been found to regulate Fas ligand (FasL) expression during activation-induced T-cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPI1 | up-regulates quantity by expression 
transcriptional regulation
|
EGR2 |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256040 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16923394 |
PU.1 Induces Egr-2 and Nab-2, which Repress Neutrophil Genes during Macrophage Differentiation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
EGR2 | down-regulates quantity by repression 
transcriptional regulation
|
GFI1 |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256041 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16923394 |
Impairing Egr-2 or Nab-2 induction resulted in sustained expression of Gfi-1, demonstrating that Egr-2 and Nab-2 negatively regulate Gfi-1 expression . Importantly, the Gfi-1 promoter was repressed via the Egr site by coexpression of Egr-2 and Nab-2. Thus, Egr-2 and Nab-2 directly repress the Gfi-1 gene. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
GFI1 | down-regulates quantity by repression
transcriptional regulation
|
EGR2 |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256133 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16923394 |
Importantly, overexpression of Gfi-1 in these cells resulted in the attenuation of both Egr-1 and Egr-2 expression, but not Nab-2. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
EGR2 | down-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260048 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11494141 |
Flow cytometry suggested that over-expression of BPOZ inhibited progression of the cell cycle at the G1/S transition. Anti-sense oligonucleotides for BPOZ or EGR2 effectively inhibited their expression, and cell growth was accelerated. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTEN | up-regulates quantity by expression
transcriptional regulation
|
EGR2 |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260049 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11494141 |
Defects in PTEN, a tumor suppressor, have been found in cancers arising in a variety of human tissues. To elucidate the tumor-suppressive function of this gene, we have been analysing expression profiles of cancer cells after introduction of exogenous PTEN. Those experiments identified 99 candidate genes that were transcriptionally transactivated. Among them, we report here the further analyses of eight genes, EGR2/Krox-20, BPOZ, APS, HCLS1/HS1, DUSP1/MKP1, NDRG1/Drg1/RTP, NFIL3/E4BP4, and a novel gene (PINK1, PTEN-induced putative kinase). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR2 | up-regulates quantity by expression 
transcriptional regulation
|
CEBPB |
0.515 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139292 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16054051 |
Ectopic expression of krox20 can transactivate the c/ebpbeta promoter and increase c/ebpbeta gene expression in 3t3-l1 preadipocytes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR2 | down-regulates quantity by repression
transcriptional regulation
|
NAB2 |
0.594 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253885 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 20506119 |
In T lymphocytes EGR2 and EGR3 have been shown to inhibit NAB2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
EGR2 | up-regulates
|
Monocyte_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256089 |
|
|
Homo sapiens |
U-937 Cell |
| pmid |
sentence |
| 1864967 |
Finally, we demonstrate that dexamethasone, an inhibitor of monocytic differentiation, blocks the associated increases in EGR-1 and EGR-2 expression. Taken together, the results indicate that the EGR-1 and EGR-2 early response genes are involved in the induction of myeloid leukemia cell differentiation along the monocytic lineage and in the activation of human monocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
EGR2 | up-regulates quantity by expression
transcriptional regulation
|
NAB2 |
0.594 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253883 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 20506119 |
In melanoma and carcinoma cells EGR1 activates NAB2 expression. we investigated the influence of EGR2 and EGR3 on NAB2 expression in melanoma and carcinoma cells. Here, we show that like EGR1, EGR2 and EGR3 induced NAB2 expression in these cells. EGR1 and EGR3 act in concert on the NAB2 promoter and are more potent activators of NAB2 transcription than EGR2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
NAB2 | down-regulates quantity by repression
transcriptional regulation
|
EGR2 |
0.594 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253888 |
|
|
Homo sapiens |
Epithelial Cell |
| pmid |
sentence |
| 20506119 |
Our results suggest that in many cells of neuroectodermal and epithelial origin EGR1, EGR2, and EGR3 activate NAB2 transcription which is in turn repressed by NAB2, thus establishing a negative feedback loop. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
3.0
EGR2
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