Relation Results

Summary

Name WWP2
Full Name NEDD4-like E3 ubiquitin-protein ligase WWP2
Synonyms Atrophin-1-interacting protein 2, AIP2, HECT-type E3 ubiquitin transferase WWP2, WW domain-containing protein 2 |
Primary ID O00308
Links - -
Type protein
Relations 9
Function E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ...
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Type: Score: Layout: SPV 
0.4640.3040.2870.20.380.20.3380.20.396WWP2POU5F1SLC11A2TP73WWP1EGR2ABI3PAIP1Ub:E2POLR2A

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Relations
Regulator
Mechanism
target
score ℹ
+ WWP2down-regulates quantity img/direct_inhibition.png ubiquitination POU5F1 0.464
Identifier Residue Sequence Organism Cell Line
SIGNOR-268850 Homo sapiens HEK-293 Cell
pmid sentence
WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells|Here, we report that human WWP2, an E3 ubiquitin (Ub)-protein ligase, interacts with OCT4 specifically through its WW domain and enhances Ub modification of OCT4 both in vitro and in vivo.
Publications: 1 Organism: Homo Sapiens
+ WWP2down-regulates quantity img/direct_inhibition.png ubiquitination SLC11A2 0.304
Identifier Residue Sequence Organism Cell Line
SIGNOR-268852 Cricetulus griseus CHO Cell
pmid sentence
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2|This promotes DMT1 ubiquitination and degradation by WWP2.
Publications: 1 Organism: Cricetulus Griseus
+ WWP2down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TP73 0.287
Identifier Residue Sequence Organism Cell Line
SIGNOR-272233 Homo sapiens HEK-293 Cell
pmid sentence
WWP2 ubiquitinates p73 and controls its protein stability. In our study, we identified WWP2, an E3 ligase, as a novel p73-associated protein that ubiquitinates and degrades p73. In contrast, WWP2 heterodimerizes with another E3 ligase, WWP1, which specifically ubiquitinates and degrades ΔNp73. 
Publications: 1 Organism: Homo Sapiens
+ WWP2up-regulates activity img/direct-activation.png binding WWP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-272231 Homo sapiens HEK-293 Cell
pmid sentence
WWP1 in complex with WWP2 specifically regulates ΔNp73.  In our study, we identified WWP2, an E3 ligase, as a novel p73-associated protein that ubiquitinates and degrades p73. In contrast, WWP2 heterodimerizes with another E3 ligase, WWP1, which specifically ubiquitinates and degrades ΔNp73. 
Publications: 1 Organism: Homo Sapiens
+ WWP2down-regulates quantity img/direct_inhibition.png ubiquitination EGR2 0.38
Identifier Residue Sequence Organism Cell Line
SIGNOR-268849 Homo sapiens HEK-293 Cell
pmid sentence
The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination|AIP2 interacts with and promotes ubiquitin-mediated degradation of EGR2, a zinc finger transcription factor that has been found to regulate Fas ligand (FasL) expression during activation-induced T-cell death.
Publications: 1 Organism: Homo Sapiens
+ WWP2down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination ABI3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-272656 in vitro
pmid sentence
The AIP2 E3 ligase acts as a novel negative regulator of ABA signaling by promoting ABI3 degradation. Here, we show that ABI3 is an unstable protein and that an ABI3-interacting protein (AIP2), which contains a RING motif, can polyubiquitinate ABI3 in vitro.
Publications: 1 Organism: In Vitro
+ WWP2down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PAIP1 0.338
Identifier Residue Sequence Organism Cell Line
SIGNOR-272842 Homo sapiens HEK-293 Cell
pmid sentence
Here, we show that the E6AP carboxyl terminus (HECT)-type ubiquitin ligase WW domain-containing protein 2 (WWP2), a homolog of the HECT-type ubiquitin ligase WWP1, interacts with and targets Paip1 for ubiquitination and proteasomal degradation.
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination WWP2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271288 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
+ WWP2down-regulates quantity img/direct_inhibition.png ubiquitination POLR2A 0.396
Identifier Residue Sequence Organism Cell Line
SIGNOR-268851 Homo sapiens U2-OS Cell
pmid sentence
WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks|In response to DSBs, WWP2 targets the RNAPII subunit RPB1 for K48-linked ubiquitylation, thereby driving DNA-PK- and proteasome-dependent eviction of RNAPII.
Publications: 1 Organism: Homo Sapiens
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