Summary

Name MMP9
Full Name Matrix metalloproteinase-9
Synonyms MMP-9, 92 kDa gelatinase, 92 kDa type IV collagenase, Gelatinase B, GELB | CLG4B
Primary ID P14780
Links - -
Type protein
Relations 15
Function May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage A2M 0.468
Publications: 2 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage HAPLN1 0.348
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage PZP 0.356
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding MMP9 0.356
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP9 0.391
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MMP9 0.373
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png cleavage TGFB1 0.616
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ up-regulates img/indirect-activation.png ECM_disassembly 0.7
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP9 0.472
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP9 0.433
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP9 0.337
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding MMP9 0.468
Publications: 1 Organism: In Vitro
+ down-regulates activity img/indirect_inhibition.png MMP9 0.272
Publications: 1 Organism: Homo Sapiens