| + |
AREG | up-regulates 
binding
|
EGFR |
0.764 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236356 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20513444 |
Remarkably, three members of the epidermal growth factor (egf) family (ereg, areg, and epgn) showed increased expression that was associated with elevated epidermal activation of the egf receptor (egfr) and stat3, a downstream effector of egfr signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-65576 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10085134 |
The epidermal growth factor receptor (EGFR) mediates the actions of a family of bioactive peptides that include epidermal growth factor (EGF) and amphiregulin (AR) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| Pathways: | EGFR Signaling |
| + |
SRC | up-regulates
cleavage
|
AREG |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236537 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
Ep2 can also promote the transactivation of epidermal growth factor receptor (egfr) expressed in colon cancer cells through src, which activates the proteolytic release of the egfr ligands amphiregulin (ar) and transforming growth factor-alfa (tgfalfa)125, thereby stimulating the egfr- network. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling |
| + |
DMTF1 | up-regulates quantity by expression
transcriptional regulation
|
AREG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261582 |
|
|
Mus musculus |
C-10 Cell |
| pmid |
sentence |
| 19816943 |
Notably, amphiregulin (Areg), thrombospondin-1 (Tsp-1), JunB, Egr1, adrenomedullin (Adm), Bcl-3 and methyl-CpG binding domain protein 1 (Mbd1) were downregulated in the lungs from Dmp1-null mice while Gas1 and Ect2 genes were upregulated. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
AREG | up-regulates activity
binding
|
EGFR |
0.764 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67000 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10209155 |
ErbB ligands include: EGF, transforming growth factor (TGF)_, and amphiregulin which only bind ErbB1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling |
| + |
SATB1 | down-regulates quantity by repression 
transcriptional regulation
|
AREG |
0.25 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255133 |
|
|
Homo sapiens |
K-562 Cell |
| pmid |
sentence |
| 17343824 |
We found 59 up-regulated and 75 down-regulated genes in the K562-SATB1 cells that were not observed in the K562 cells. Partial genes that have special biological functions are listed in Table 1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AREG | up-regulates
phosphorylation
|
ERBB2 |
0.615 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-31199 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7679104 |
Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WT1 | up-regulates quantity by expression
transcriptional regulation
|
AREG |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251745 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10490105 |
The Wilms Tumor Suppressor WT1 Encodes a Transcriptional Activator of amphiregulin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F2RL1 | up-regulates quantity by expression 
transcriptional regulation
|
AREG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254855 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21072196 |
PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2) and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADAM17 | up-regulates activity
cleavage
|
AREG |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259842 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26284334 |
ADAM17 is involved in the release and activation of several growth factors and cytokine receptor ligands. Among the growth factors activated by ADAM17 are TGF-alpha, amphiregulin, epiregulin and HB-EGF |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
AREG
- 
- 