| + |
GSK3B | down-regulates activity 
phosphorylation
|
MUC1 |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249356 |
Ser1227 |
PPSSTDRsPYEKVSA |
|
HeLa Cell |
| pmid |
sentence |
| 9819408 |
GSK3beta binds directly to an STDRSPYE site in MUC1 and phosphorylates the serine adjacent to proline. Phosphorylation of MUC1 by GSK3beta decreases binding of MUC1 to beta-catenin in vitro and in vivo. |
|
| Publications: |
1 |
| + |
PRKCD | up-regulates 
phosphorylation
|
MUC1 |
0.342 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-115501 |
Thr1224 |
RYVPPSStDRSPYEK |
Homo sapiens |
|
| pmid |
sentence |
| 11877440 |
We show that phosphorylation of muc1 by pkcdelta increases binding of muc1 and beta-catenin in vitro and in vivo. The functional significance of the muc1-pkcdelta interaction is further supported by the demonstration that mutation of the pkcdelta phosphorylation site abrogates muc1-mediated decreases in binding of beta-catenin to e-cadherin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZAP70 | up-regulates activity
phosphorylation
|
MUC1 |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-247039 |
Tyr1203 |
IFPARDTyHPMSEYP |
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 14766232 |
Indeed, the present results demonstrate that ZAP-70 phosphorylates MUC1-CD and that the MUC1-CD Y-20 site functions, at least in part, as a ZAP-70 substrate (Fig. 4C). In this regard, the in vivo phosphorylation data indicate that ZAP-70 may also contribute to phosphorylation of MUC1-CD Y-46.The results further show that ZAP-70 phosphorylation of MUC1-CD stimulates the interaction of MUC1 andBeta-catenin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGFR | up-regulates activity
phosphorylation
|
MUC1 |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109538 |
Tyr1229 |
SSTDRSPyEKVSAGN |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 11483589 |
We also show that the activated egf-r phosphorylates the muc1 cytoplasmic tail on tyrosine at a yekv motif that functions as a binding site for the c-src sh2 domain. The results demonstrate that egf-r-mediated phosphorylation of muc1 induces binding of muc1 to c-src in cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LCK | up-regulates activity
phosphorylation
|
MUC1 |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-247058 |
Tyr1229 |
SSTDRSPyEKVSAGN |
Homo sapiens |
|
| pmid |
sentence |
| 14766232 |
The present results demonstrate that Lck phosphorylation of MUC1 on Y-46 also increases binding of MUC1 and _-catenin. The results further show that ZAP-70 phosphorylation of MUC1-CD stimulates the interaction of MUC1 and _-catenin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249358 |
Tyr1229 |
SSTDRSPyEKVSAGN |
|
JURKAT Cell |
| pmid |
sentence |
| 14766232 |
The present results demonstrate that Lck phosphorylation of MUC1 on Y-46 also increases binding of MUC1 and beta-catenin. The results further show that ZAP-70 phosphorylation of MUC1-CD stimulates the interaction of MUC1 and beta-catenin |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, |
| + |
SRC | up-regulates
phosphorylation
|
MUC1 |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-85938 |
Tyr1229 |
SSTDRSPyEKVSAGN |
Homo sapiens |
|
| pmid |
sentence |
| 11152665 |
The c-src tyrosine kinase regulates signaling of the human df3/muc1 carcinoma-associated antigen with gsk3 beta and betBeta-catenin c-src phosphorylates the muc1 cytoplasmic domain at a yekv motif c-src-mediated phosphorylation of muc1 increases binding of muc1 and betBeta-catenin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL1 | up-regulates quantity by stabilization
phosphorylation
|
MUC1 |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260830 |
Tyr1243 |
NGGSSLSyTNPAVAA |
Homo sapiens |
|
| pmid |
sentence |
| 16888623 |
The results demonstrate that ABL1 phosphorylates MUC1 on Tyr-60 and forms a complex with MUC1 by binding of the ABL1 SH2 domain to the pTyr-60 site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MUC1 | up-regulates activity
binding
|
KLF4 |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270543 |
|
|
|
|
| pmid |
sentence |
| 17308127 |
Previous work has shown that the Kruppel-like factor 4 (KLF4) transcription factor represses p53 transcription by binding to the PE21 element. Our results show that MUC1-C binds constitutively to KLF4, occupies PE21 with KLF4, and enhances the KLF4 occupancy of PE21. |
|
| Publications: |
1 |
| + |
ADAM17 | down-regulates
cleavage
|
MUC1 |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-95630 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12441351 |
These characteristics along with studies conducted with cell lines genetically deficient in various adams (for a disintegrin and metalloprotease) identified tumor necrosis factor-alpha converting enzyme (tace)/adam 17 as a muc1 sheddase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MUC1
- 
- 