Summary

Name XBP1
Full Name X-box-binding protein 1
Synonyms XBP-1, Tax-responsive element-binding protein 5, TREB-5 | TREB5, XBP2
Primary ID P17861
Links - -
Type protein
Relations 14
Function Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity).

Viewer

Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation XBP1 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NPPB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png post transcriptional regulation XBP1 (isoform 2) 0.64
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ down-regulates img/indirect_inhibition.png Unfolded_Proteins 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ up-regulates activity img/direct-activation.png binding XBP1 0.2
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation XBP1 (isoform 2) 0.683
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ up-regulates quantity by stabilization img/direct-activation.png acetylation XBP1 (isoform 2) 0.291
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ up-regulates quantity img/direct-activation.png relocalization XBP1 (isoform 2) 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV ER STRESS
+ up-regulates img/indirect-activation.png Chaperone-mediated protein folding 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png B-Lymphocyte_diff 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding XBP1 0.307
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png binding XBP1 0.322
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png binding XBP1 0.308
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png deacetylation XBP1 (isoform 2) 0.393
Publications: 1 Organism: Homo Sapiens