Summary

Name NF2
Full Name Merlin
Synonyms Moesin-ezrin-radixin-like protein, Neurofibromin-2, Schwannomerlin, Schwannomin | SCH
Primary ID P35240
Links - -
Type protein
Relations 19
Pathways Hippo Signaling, YAP/TAZ regulation
Function Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png ubiquitination NF2 0.264
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ up-regulates img/direct-activation.png phosphorylation NF2 0.384
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NF2
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation NF2 0.384
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NF2 0.384
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NF2 0.633
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NF2 0.495
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LATS2 0.711
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ up-regulates activity img/direct-activation.png binding STK3 0.332
Publications: 1 Organism: Mus Musculus
Pathways:Hippo Signaling
+ up-regulates activity img/direct-activation.png binding STK4 0.421
Publications: 1 Organism: Mus Musculus
Pathways:Hippo Signaling
+ down-regulates img/direct_inhibition.png phosphorylation NF2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LATS1 0.708
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ up-regulates activity img/direct-activation.png binding STK3/4 0.421
Publications: 1 Organism: Mus Musculus
Pathways:Hippo Signaling
+ up-regulates activity img/direct-activation.png binding LATS1/2 0.756
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination NF2 0.332
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding NF2 0.2
Publications: 1 Organism: Homo Sapiens