Summary

Name IL1RN
Full Name Interleukin-1 receptor antagonist protein
Synonyms IL-1RN, IL-1ra, IRAP, ICIL-1RA, IL1 inhibitor | IL1F3, IL1RA
Primary ID P18510
Links - -
Type protein
Relations 4
Pathways IL1 Signaling , SARS-CoV CYTOKINE STORM
Function Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

Viewer

Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL1RN 0.483
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ down-regulates activity img/direct_inhibition.png binding IL1R1 0.893
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling , SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL1RN 0.341
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling , SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL1RN 0.601
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM