| + |
MAP3K14 | up-regulates activity 
phosphorylation
|
CHUK |
0.677 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55942 |
Ser176 |
AKDVDQGsLCTSFVG |
Homo sapiens |
|
| pmid |
sentence |
| 9520446 |
Nf-kappab-inducing kinase activates ikk-alpha by phosphorylation of ser-176. Nik preferentially phosphorylates ikk-alpha over ikk-beta, leading to the activation of ikk-alpha kinase activity; the accumulated nik phosphorylates ikkalfa. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55946 |
Ser180 |
DQGSLCTsFVGTLQY |
Homo sapiens |
|
| pmid |
sentence |
| 9520446 |
NIK preferentially phosphorylates ikk-alpha over ikk-beta, leading to the activation of ikk-alpha kinase activity; the accumulated nik phosphorylates ikkalfa. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167060 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20651737 |
Once activated by autophosphorylation, nik activates ikkalpha, which in turn phosphorylates nf-kb2. This stimulates limited proteasome-mediated proteolysis of nf-kb2 to p52. Removal of the carboxy-terminal ankyrin repeats from nf-kb2 releases the p52/RELB heterodimer, allowing its translocation to the nucleus where it instigates the expression of nf-kb target genes. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | NF-KB Non Canonical |
| + |
MAP3K14 | up-regulates activity
phosphorylation
|
NFKB2 |
0.662 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105553 |
Ser866 |
TAEVKEDsAYGSQSV |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11239468 |
NIK-induced p100 processing requires phosphorylation of p100 at serines 866 and 870 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105557 |
Ser870 |
KEDSAYGsQSVEQEA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11239468 |
NIK-induced p100 processing requires phosphorylation of p100 at serines 866 and 870 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | NF-KB Non Canonical |
| + |
CHUK | down-regulates quantity by destabilization 
phosphorylation
|
MAP3K14 |
0.677 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165622 |
Thr559 |
TGDYIPGtETHMAPE |
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 20501937 |
Upon activation by nik, ikkalfa phosphorylates nik, triggering its proteolysis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NF-KB Non Canonical |
| + |
MAP3K8 | up-regulates activity
phosphorylation
|
MAP3K14 |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249387 |
Thr559 |
TGDYIPGtETHMAPE |
Homo sapiens |
|
| pmid |
sentence |
| 9742107 |
In studies of NIK, we found that Thr-559 located within the activation loop of its kinase domain regulates NIK action. Alanine substitution of Thr-559 but not other serine or threonine residues within the activation loop abolishes its activity and its ability to phosphorylate and activate IKKalpha |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRAF6 | up-regulates activity
binding
|
MAP3K14 |
0.615 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253048 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10075662 |
RANK activates NF-κB by interacting with TRAF6 via a novel TRAF6 interaction motif and TRAF6 potentially activates NIK, leading to NF-κB activation. TRAF6 has been demonstrated to interact with NIK. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Innate Immune Response |
| + |
MAP3K14 | up-regulates activity
phosphorylation
|
MAP3K14 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167063 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20651737 |
As nik levels increase, nik presumably becomes activated by autophosphorylation (p). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Innate Immune Response, NF-KB Non Canonical |
| + |
TRAF2 | down-regulates quantity by destabilization
ubiquitination, binding
|
MAP3K14 |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167066 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20651737 |
Under resting conditions cellular inhibitor of apoptosis (ciap) proteins target nuclear factor-kb (nf-kb)-inducing kinase (nik) for ubiquitylation and proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124233 |
|
|
Mus musculus |
Lymphoma Cell |
| pmid |
sentence |
| 15084608 |
We report here that one important mechanism of nik regulation is through its dynamic interaction with the tumor necrosis factor receptor-associated factor 3 (traf3). Traf3 physically associates with nik via a specific sequence motif located in the n-terminal region of nik; this molecular interaction appears to target nik for degradation by the proteasome. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | NF-KB Non Canonical |
| + |
MAP3K14 | up-regulates
phosphorylation
|
IKK-complex |
0.706 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217433 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9520446 |
Nf-kappab-inducing kinase activates ikk-alpha by phosphorylation of ser-176.Nik preferentially phosphorylates ikk-alpha over ikk-beta, leading to the activation of ikk-alpha kinase activity; the accumulated nik phosphorylates ikkalfa. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Innate Immune Response, NF-KB Non Canonical |
| + |
TRAF3 | down-regulates quantity by destabilization
binding
|
MAP3K14 |
0.651 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124236 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15084608 |
Traf3 is physically associated with nik via a specific sequence motif located in the n-terminal region of nik; this molecular interaction appears to target nik for degradation by the proteasome. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Innate Immune Response, NF-KB Non Canonical |
| + |
TRAF2 | up-regulates activity
binding
|
MAP3K14 |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46215 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9020361 |
NIK binds to Traf2 and stimulates NF-kappaB activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NF-KB Non Canonical |
| + |
TRAPPC9 | up-regulates activity
binding
|
MAP3K14 |
0.502 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269672 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15951441 |
We demonstrated by immunohistochemistry that NIBP expression in the brain is localized to neurons. NIBP physically interacts with NIK, IKK(beta), but not IKK(alpha) or IKK(gamma). NIBP overexpression potentiates tumor necrosis factor-alpha-induced NF-kappaB activation through increased phosphorylation of the IKK complex and its downstream I(kappa)B(alpha) and p65 substrates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZFP91 | up-regulates
ubiquitination
|
MAP3K14 |
0.52 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167331 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20682767 |
Zfp91 interacts with and promotes the lys(63)-linked ubiquitination of nik and subsequent processing of p100 to p52. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K14 | up-regulates 
|
NfKb-p65/p50 |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46212 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9020361 |
Nik stimulates nf-kappab activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Innate Immune Response |
| + |
BIRC3 | down-regulates
ubiquitination
|
MAP3K14 |
0.632 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167298 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20682767 |
Ciap1/2 (cellular inhibitor of apoptosis 1 and 2) ubiquitinate nik for degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
MAP3K14 |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262833 |
|
|
|
|
| pmid |
sentence |
| 10094049 |
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway|Activated TAK1 phosphorylates NIK, which stimulates IKK-alpha activity. Our results indicate that TAK1 links TRAF6 to the NIK-IKK cascade in the IL-1 signalling pathway. |
|
| Publications: |
1 |
| + |
MAP3K14 | up-regulates
phosphorylation
|
IKBKB |
0.694 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55949 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9520446 |
Activation of the transcription factor nf-kappab by inflammatory cytokines involves the successive action of nf-kappab-inducing kinase (nik) and two ikappab kinases, ikk-alpha and ikk-beta. Here we show that nik preferentially phosphorylates ikk-alpha over ikk-beta |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MAP3K14
- 
- 