Summary

Name IL4R
Full Name Interleukin-4 receptor subunit alpha
Synonyms IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha, IL-4RA | IL4RA
Primary ID P24394
Links - -
Type protein
Relations 16
Pathways FAP: IL4/IL13 induction, Macrophage polarization, Macrophage: IL4, Macrophage: Polarization and myogenesis, Multiple sclerosis, T-Lymphocyte: IL4 and its transcriptional regulation
Function Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding IL4R 0.941
Publications: 2 Organism: In Vitro, Homo Sapiens
Pathways:Macrophage polarization, Multiple sclerosis
+ up-regulates img/indirect-activation.png JAK3 0.661
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png STAT5A 0.535
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IRS2 0.571
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Lung, Smooth Muscle
+ up-regulates img/direct-activation.png binding IL4R 0.892
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization
+ up-regulates img/direct-activation.png binding IL2RG 0.82
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Lung, Smooth Muscle
+ up-regulates img/direct-activation.png phosphorylation IRS1 0.542
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Lung, Smooth Muscle
+ up-regulates activity img/direct-activation.png phosphorylation JAK1 0.705
Publications: 1 Organism: Homo Sapiens
Pathways:Multiple sclerosis
+ up-regulates activity img/direct-activation.png binding IL4R 0.892
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization
+ up-regulates activity img/indirect-activation.png Proliferation 0.7
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding JAK1 0.705
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Lung, Smooth Muscle
Pathways:Multiple sclerosis
+ up-regulates activity img/direct-activation.png binding IL4R 0.941
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization, Multiple sclerosis
+ up-regulates activity img/direct-activation.png phosphorylation JAK2 0.605
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization
+ up-regulates img/indirect-activation.png JAK1 0.705
Publications: 1 Organism: Homo Sapiens
Pathways:Multiple sclerosis