Macrophage: Polarization and myogenesis

Pathway ID: SIGNOR-MacroPol

Description: Macrophages display a peculiar plasticity, being able to polarize into M1 (pro-inflammatory) and M2 (anti-inflammatory) phenotypes, depending on the environmental cues. They participate in muscle regeneration by orchestrating the healing of the injured tissue: a first wave of pro-inflammatory macrophages that promote the clearance of necrotic debris is followed by a second wave of anti-inflammatory macrophages that sustain tissue healing.

Curated by: Alessandro Palma

33 Seed Entities

Organism:
Name Primary ID
IL10 P22301
IL6R P08887
IL4 P05112
IL4R P24394
IL1R1 P14778
STAT3 P40763
SMAD2/SMAD4 SIGNOR-C8
SMAD2 Q15796
RIPK1 Q13546
TNF P01375
JAK1 P23458
M2_polarization SIGNOR-PH55
IKK-complex SIGNOR-C14
JAK2 O60674
IL1B P01584
SOCS1 O15524
NfKb-p65/p50 SIGNOR-C13
TNFRSF1A P19438
IL6ST P40189
IL6 P05231
TGFB1 P01137
STAT6 P42226
IL10RA Q13651
M1_polarization SIGNOR-PH54
IRAK1 P51617
IL13 P35225
PPARG P37231
SOCS3 O14543
SMAD4 Q13485
SMAD3 P84022
TRADD Q15628
STAT1 P42224
TGFBR1 P36897