Relation Results

Summary

Name	ID1 View Modifications
Full Name	DNA-binding protein inhibitor ID-1
Synonyms	Class B basic helix-loop-helix protein 24, bHLHb24, Inhibitor of DNA binding 1, Inhibitor of differentiation 1 \| BHLHB24, ID
Primary ID	P41134
Links	- -
Type	protein
Relations	18
Pathways	Acute Myeloid Leukemia, FLT3 in AML, miRNA in AML
Function	Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

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Regulator

Mechanism

target

score ℹ

CAMK2A

up-regulates activity img/direct-activation.png

phosphorylation