| + |
TCF4 | up-regulates quantity by expression 
transcriptional regulation
|
ABCB1 |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255389 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20459685 |
Cd2+ reduced the interaction of beta-catenin with AJ components (E-cadherin, alpha-catenin) and increased binding to the transcription factor TCF4 of the Wnt pathway, which was upregulated and translocated to the nucleus. While Wnt target genes (c-Myc, cyclin D1 and ABCB1) were up-regulated by Cd2+, electromobility shift assays showed increased TCF4 binding to cyclin D1 and ABCB1 promoter sequences with Cd2+. Overexpression of wild-type and mutant TCF4 confirmed Cd2+-induced Wnt signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TCF4 | up-regulates quantity by expression
transcriptional regulation
|
CNTNAP2 |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255390 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22777675 |
we show that TCF4 can transactivate the NRXN1β and CNTNAP2 promoters in luciferase assays. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXB13 | down-regulates quantity by repression 
transcriptional regulation
|
TCF4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254476 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 15928669 |
In prostate cancers, HOXB13 negatively regulates beta-catenin/TCF4-mediated transactivation and subsequently inhibits cell growth. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NLK | down-regulates 
phosphorylation
|
TCF4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-24147 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2861485 |
Whereas lef-1 and tcf-4 phosphorylation by nlk (nemo-like kinase) leads to less lef/tcf/beta-catenin complex binding to dna and to lef-1/tcf-4 degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates activity 
binding
|
TCF4 |
0.678 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178042 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11713476 |
beta-catenin interacts with the TCF/Lef family transcription factors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor, WNT/FLT3 |
| + |
TCF4 | up-regulates quantity by expression
transcriptional regulation
|
SOX9 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253323 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15240568 |
The β-catenin–TCF4 complex activity is required for SOX9 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TCF4 | up-regulates quantity by expression
transcriptional regulation
|
NRXN1 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255391 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22777675 |
we show that TCF4 can transactivate the NRXN1β and CNTNAP2 promoters in luciferase assays. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ID2 | down-regulates activity
binding
|
TCF4 |
0.614 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241376 |
|
|
Mus musculus |
C3H10T1/2 Cell |
| pmid |
sentence |
| 9242638 |
All three Ids bound with high affinity to E proteins .Each Id was able to disrupt the ability of E protein-MyoD complexes to transactivate from a muscle creatine kinase reporter construct in vivo. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ID3 | down-regulates activity
binding
|
TCF4 |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241379 |
|
|
Mus musculus |
C3H10T1/2 Cell |
| pmid |
sentence |
| 9242638 |
All three Ids bound with high affinity to E proteins .Each Id was able to disrupt the ability of E protein-MyoD complexes to transactivate from a muscle creatine kinase reporter construct in vivo. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TCF4 | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253324 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18852287 |
Association of c-Jun, β-catenin, and TCF4 specifically with the downstream enhancer underlies mitogen stimulation of c-Myc transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor, WNT/FLT3 |
| + |
JUN | up-regulates
binding
|
TCF4 |
0.401 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138544 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16007074 |
Phosphorylation-dependent interaction between c-jun and tcf4;c-jun and tcf4 cooperatively activated the c-jun promoter in reporter assays |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT/FLT3 |
| + |
ID1 | down-regulates activity
binding
|
TCF4 |
0.647 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241385 |
|
|
Mus musculus |
C3H10T1/2 Cell |
| pmid |
sentence |
| 9242638 |
All three Ids bound with high affinity to E proteins .Each Id was able to disrupt the ability of E protein-MyoD complexes to transactivate from a muscle creatine kinase reporter construct in vivo. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO1 | down-regulates activity
binding
|
TCF4 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262529 |
|
|
Homo sapiens |
Colonic Cancer Cell Line |
| pmid |
sentence |
| 18250171 |
Here we show that the beta-catenin binding to FOXO serves a dual effect. beta-catenin, through binding, enhances FOXO transcriptional activity. In addition, FOXO competes with TCF for interaction with beta-catenin, thereby inhibiting TCF transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT/FLT3 |
| + |
TCF4 | up-regulates quantity by expression
transcriptional regulation
|
SSTR2 |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261618 |
|
|
Mus musculus |
Neuro-2a Cell |
| pmid |
sentence |
| 10207097 |
Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TCF4 | up-regulates quantity by expression
transcriptional regulation
|
CCND1 |
0.345 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255388 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20459685 |
Cd2+ reduced the interaction of beta-catenin with AJ components (E-cadherin, alpha-catenin) and increased binding to the transcription factor TCF4 of the Wnt pathway, which was upregulated and translocated to the nucleus. While Wnt target genes (c-Myc, cyclin D1 and ABCB1) were up-regulated by Cd2+, electromobility shift assays showed increased TCF4 binding to cyclin D1 and ABCB1 promoter sequences with Cd2+. Overexpression of wild-type and mutant TCF4 confirmed Cd2+-induced Wnt signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TCF4 | form complex 
binding
|
MYOD/E2-2 |
0.691 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241382 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16847330 |
The MyoD family of basic helix-loop-helix transcription factors function as heterodimers with members of the E-protein family to induce myogenic gene activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TCF4
- 
- 