4.0
Summary
| Name |  PML-RARalpha
|
| Primary ID | SIGNOR-FP2 |
| Type | Fusion Protein |
| Formed by | P29590, P10276 |
| Description | A fusion gene that results from a chromosomal translocation t(15;17)(q22;q21) which fuses the first 3 exons of the PML gene with the last 7 exons of the RARA gene. Acute promyelocytic leukemia is characterized by this fusion protein. Three transcript variants are possible based on the three breakpoint clusters in the PML gene. The chimeric protein (797 aa, ~106 kDa), that is encoded by the PML/RARA fusion gene, contains the B-box and the RING-finger domain from protein PML and the DNA-binding domain, ligand binding domain and coactivator recognition site from the retinoic acid receptor alpha protein. |
| Sequence | MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQCQAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYRQIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDGTRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEELDAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEAVDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLRQEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPEEAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCSQTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLPNSNHVASGAGEATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP |
| Relations | 19 |
| Pathways | Acute Myeloid Leukemia, FLT3 in AML, Onco-fusion proteins in AML |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | diarsenic trioxide | down-regulates quantity by destabilization 
chemical inhibition
|
PML-RARalpha | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML | |||
| + | PML-RARalpha | up-regulates activity 
|
JUN | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia | |||
| + | PML-RARalpha | up-regulates 
|
Proliferation | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, Onco-fusion proteins in AML | |||
| + | PML-RARalpha | up-regulates activity
|
CCNA1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, Onco-fusion proteins in AML | |||
| + | PML-RARalpha | up-regulates quantity by expression
transcriptional regulation
|
ID2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PML-RARalpha | up-regulates activity
binding
|
SP1 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens, In Vitro | |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML | |||
| + | PML-RARalpha | up-regulates activity
|
AP1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, Onco-fusion proteins in AML | |||
| + | RXRA | up-regulates activity
binding
|
PML-RARalpha | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | Acute Myeloid Leukemia | |||
| + | PML-RARalpha | up-regulates activity
binding
|
GATA2 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | PML-RARalpha | down-regulates 
|
Differentiation | 0.7 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, Onco-fusion proteins in AML | |||
| + | PML-RARalpha | up-regulates activity
|
MYC | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML | |||
| + | PML-RARalpha | down-regulates quantity by repression
transcriptional regulation
|
CEBPA | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, Onco-fusion proteins in AML | |||
| + | PML-RARalpha | up-regulates quantity by expression
transcriptional regulation
|
ID1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML | |||
| + | PML-RARalpha | up-regulates quantity
transcriptional regulation
|
MYB | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PML-RARalpha | up-regulates activity
binding
|
NFY | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML | |||
| + | PML-RARalpha | up-regulates quantity by expression
transcriptional regulation
|
CCNA1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, Onco-fusion proteins in AML | |||
| + | all-trans-retinoic acid | down-regulates quantity by destabilization
chemical inhibition
|
PML-RARalpha | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML | |||