Summary

Name PRKCI
Full Name Protein kinase C iota type
Synonyms Atypical protein kinase C-lambda/iota, PRKC-lambda/iota, aPKC-lambda/iota, nPKC-iota | DXS1179E
Primary ID P41743
Links - -
Type protein
Relations 19
Function Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ PRKCIdown-regulates img/direct_inhibition.png phosphorylation BAD 0.324
Publications: 3 Organism: Homo Sapiens
+ PRKCIdown-regulates activity img/direct_inhibition.png phosphorylation FBXW7 0.27
Publications: 1 Organism: Homo Sapiens
+ PRKCIdown-regulates activity img/direct_inhibition.png phosphorylation MAPT (isoform 2) 0.269
Publications: 1 Organism: In Vitro
+ PRKCIup-regulates activity img/direct-activation.png phosphorylation VIM 0.2
Publications: 1 Organism: Homo Sapiens
+ PRKCIup-regulates quantity by stabilization img/direct-activation.png phosphorylation PARD6A 0.86
Publications: 1 Organism: Homo Sapiens
+ PRKCIup-regulates activity img/direct-activation.png phosphorylation LLGL2 0.709
Publications: 1 Organism: Canis Lupus Familiaris
+ PRKCIup-regulates activity img/direct-activation.png phosphorylation LLGL1 0.651
Publications: 1 Organism: Canis Lupus Familiaris
+ PRKCIup-regulates img/direct-activation.png phosphorylation ECT2 0.488
Publications: 1 Organism: Homo Sapiens
+ PRKCIdown-regulates activity img/direct_inhibition.png phosphorylation NOS3 0.2
Publications: 1 Organism: Homo Sapiens
+ PRKCIup-regulates img/direct-activation.png phosphorylation EZR 0.35
Publications: 1 Organism: Homo Sapiens
+ SRCup-regulates img/direct-activation.png phosphorylation PRKCI 0.512
Publications: 3 Organism: Homo Sapiens
+ RAB2Adown-regulates activity img/direct_inhibition.png binding PRKCI 0.468
Publications: 1 Organism: Homo Sapiens
+ 1,2-diacyl-sn-glycerolup-regulates activity img/direct-activation.png binding PRKCI 0.8
Publications: 1 Organism: Homo Sapiens
+ PRKCIdown-regulates img/direct_inhibition.png phosphorylation NUMB 0.761
Publications: 1 Organism: Homo Sapiens
+ VCB-Cul2down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PRKCI 0.367
Publications: 1 Organism: Homo Sapiens