Summary

Name TERF1
Full Name Telomeric repeat-binding factor 1
Synonyms NIMA-interacting protein 2, TTAGGG repeat-binding factor 1, Telomeric protein Pin2/TRF1 | PIN2, TRBF1, TRF, TRF1
Primary ID P54274
Links - -
Type protein
Relations 9
Function Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TERF1 0.348
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TERF1 0.596
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TERF1 0.387
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TERF1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TERF1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ADP-ribosylation TERF1 0.572
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png relocalization TERF1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ADP-ribosylation TERF1 0.796
Publications: 1 Organism: In Vitro
+ form complex img/form-complex.png binding Shelterin complex 0.742
Publications: 1 Organism: Homo Sapiens