| + |
TBX21 | down-regulates quantity by repression 
transcriptional regulation
|
IL2 |
0.495 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266233 |
|
|
Mus musculus |
EL-4 Cell |
| pmid |
sentence |
| 10761931 |
T-bet Transactivates the IFNγ Gene and Represses the IL-2 Gene in EL4 Cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IL2 | up-regulates 
binding
|
IL2RB |
0.863 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144540 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16477002 |
Il-2 is a cytokine that functions as a growth factor and central regulator in the immune system and mediates its effects through ligand-induced hetero-trimerization of the receptor subunits il-2r alpha, il-2r beta, and gamma(c). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREM | down-regulates quantity by repression
transcriptional regulation
|
IL2 |
0.499 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261576 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 12626549 |
In this study we show that CREM is transcriptionally induced in T cells following stimulation through CD3 and CD28, binds to the IL-2 promoter in vivo, and suppresses IL-2 production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL2 | up-regulates quantity by expression 
transcriptional regulation
|
NAB2 |
0.362 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253894 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22128144 |
We observe that the CD8(+) T-cell autocrine growth factor IL-2 coordinately increases Nab2 expression and decreases TRAIL expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL2 | up-regulates
binding
|
IL2RG |
0.859 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144543 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16477002 |
Il-2 is a cytokine that functions as a growth factor and central regulator in the immune system and mediates its effects through ligand-induced hetero-trimerization of the receptor subunits il-2r alpha, il-2r beta, and gamma(c). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL2 | down-regulates quantity by repression 
transcriptional regulation
|
TNFSF10 |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253895 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22128144 |
We observe that the CD8(+) T-cell autocrine growth factor IL-2 coordinately increases Nab2 expression and decreases TRAIL expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL2 | up-regulates
binding
|
IL2RA |
0.926 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144537 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16477002 |
Il-2 is a cytokine that functions as a growth factor and central regulator in the immune system and mediates its effects through ligand-induced hetero-trimerization of the receptor subunits il-2r alpha, il-2r beta, and gamma(c). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFATC1 | up-regulates quantity by expression
transcriptional regulation
|
IL2 |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275405 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10022916 |
Together, our results demonstrate that dnNFAT inhibits the production of IL-2. Thus, the NFAT transcription factor contributes to the regulation of IL-2 gene expression and therefore plays a critical role in the initiation of immune responses. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IL2
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