| + |
TGFB1 | up-regulates quantity by expression 
transcriptional regulation
|
ACTA2 |
0.438 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251923 |
|
|
Homo sapiens |
Lung Fibroblast |
| pmid |
sentence |
| 20846954 |
We used diploid human lung fibroblasts (WI38 cells) induced by TGFβ to differentiate into myofibroblast-like cells. In order to characterize this system, we first studied the expression of the myofibroblast marker genes ACTA2 (coding for smooth muscle α-actin; SMA), COL4A1 (encoding collagen type IV α1) and SM22A (coding for smooth muscle protein 22-α). As shown in Figure 1A and B, TGFβ induced the expression all three genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXB8 | down-regulates quantity by repression 
transcriptional regulation
|
ACTA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261641 |
|
|
Rattus norvegicus |
A10 Cell |
| pmid |
sentence |
| 15886193 |
Results from these experiments demonstrated that in 10T1/2 cells Hoxa10-1 increased the activity of the telokin promoter 3-fold without affecting the activity of the other promoters analyzed (Fig. 2A). Similar results were also observed in A10 SMC (data not shown). In contrast, Hoxb8 significantly repressed the activity of the telokin, smooth muscle α-actin, and SM22α promoters by 70, 50, and 70%, respectively |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
SRF | up-regulates quantity by expression
transcriptional regulation
|
ACTA2 |
0.441 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126923 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15269336 |
The primary goal of the present study was to directly assess the role of the degeneracy of sm ?-Actin cargs in the regulation of smc-selective gene expression in vivo. in addition, our present studies address the possible role of this carg degeneracy, and the smc-selective srf coactivator myocardin, in regulating differential expression of carg-dependent smc genes and growth regulatory genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Smooth Muscle |
3.0
ACTA2
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