Summary

Name MC1R
Full Name Melanocyte-stimulating hormone receptor
Synonyms MSH-R, Melanocortin receptor 1, MC1-R | MSHR
Primary ID Q01726
Links - -
Type protein
Relations 22
Function Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:1325670, PubMed:8463333, PubMed:1516719, PubMed:11442765, PubMed:11707265). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:1325670, PubMed:11707265, PubMed:16463023, PubMed:19737927). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (PubMed:31097585).

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding MC1R 0.51
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates img/indirect-activation.png Pigmentation 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MC1R 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding MC1R 0.46
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png binding MC1R 0.357
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png binding GNAS 0.453
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png binding MC1R 0.735
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/indirect_inhibition.png transcriptional regulation MC1R 0.296
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MC1R 0.758
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png binding MC1R 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png chemical activation MC1R 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TNF 0.296
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAQ 0.355
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MC1R 0.265
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MC1R 0.32
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png palmitoylation MC1R 0.279
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MC1R 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MC1R 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA14 0.251
Publications: 1 Organism: Homo Sapiens