| + |
PRKACA | down-regulates 
phosphorylation
|
PLCB3 |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79148 |
Ser1105 |
LDRKRHNsISEAKMR |
Homo sapiens |
|
| pmid |
sentence |
| 10893237 |
These data indicate that pkc and pka act similarly in that they inhibit galpha(q)-stimulated plcbeta(3) as a result of phosphorylation of ser(1105). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKG1 | down-regulates activity
phosphorylation
|
PLCB3 |
0.552 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249077 |
Ser1105 |
LDRKRHNsISEAKMR |
Rattus norvegicus |
Smooth Muscle Cell |
| pmid |
sentence |
| 11278298 |
PKG can directly phosphorylate PLC-beta2 and PLC-beta3 in vitro with purified proteins and in vivo with metabolic labeling. Phosphorylation of PLC-beta leads to the inhibition of G-protein-activated PLC-beta3 activity by 50-70% in COS-7 cell transfection assays. By using phosphopeptide mapping and site-directed mutagenesis, we further identified two key phosphorylation sites for the regulation of PLC-beta3 by PKG (Ser(26) and Ser(1105)). Mutation at these two sites (S26A and S1105A) of PLC-beta3 completely blocked the phosphorylation of PLC-beta3 protein catalyzed by PKG. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249079 |
Ser26 |
VETLRRGsKFIKWDE |
Rattus norvegicus |
Smooth Muscle Cell |
| pmid |
sentence |
| 11278298 |
PKG can directly phosphorylate PLC-beta2 and PLC-beta3 in vitro with purified proteins and in vivo with metabolic labeling. Phosphorylation of PLC-beta leads to the inhibition of G-protein-activated PLC-beta3 activity by 50-70% in COS-7 cell transfection assays. By using phosphopeptide mapping and site-directed mutagenesis, we further identified two key phosphorylation sites for the regulation of PLC-beta3 by PKG (Ser(26) and Ser(1105)). Mutation at these two sites (S26A and S1105A) of PLC-beta3 completely blocked the phosphorylation of PLC-beta3 protein catalyzed by PKG. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus |
| + |
PRKCA | down-regulates
phosphorylation
|
PLCB3 |
0.503 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-58859 |
Ser1105 |
LDRKRHNsISEAKMR |
Homo sapiens |
|
| pmid |
sentence |
| 9660757 |
These data establish that direct phosphorylation by pka of ser1105 in the putative g-box of plcbeta3 inhibits galphaq-stimulated plcbeta3 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKG2 | down-regulates activity
phosphorylation
|
PLCB3 |
0.54 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249078 |
Ser1105 |
LDRKRHNsISEAKMR |
Rattus norvegicus |
|
| pmid |
sentence |
| 11278298 |
PKG can directly phosphorylate PLC-beta2 and PLC-beta3 in vitro with purified proteins and in vivo with metabolic labeling. Phosphorylation of PLC-beta leads to the inhibition of G-protein-activated PLC-beta3 activity by 50-70% in COS-7 cell transfection assays. By using phosphopeptide mapping and site-directed mutagenesis, we further identified two key phosphorylation sites for the regulation of PLC-beta3 by PKG (Ser(26) and Ser(1105)). Mutation at these two sites (S26A and S1105A) of PLC-beta3 completely blocked the phosphorylation of PLC-beta3 protein catalyzed by PKG. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249080 |
Ser26 |
VETLRRGsKFIKWDE |
Rattus norvegicus |
Smooth Muscle Cell |
| pmid |
sentence |
| 11278298 |
PKG can directly phosphorylate PLC-beta2 and PLC-beta3 in vitro with purified proteins and in vivo with metabolic labeling. Phosphorylation of PLC-beta leads to the inhibition of G-protein-activated PLC-beta3 activity by 50-70% in COS-7 cell transfection assays. By using phosphopeptide mapping and site-directed mutagenesis, we further identified two key phosphorylation sites for the regulation of PLC-beta3 by PKG (Ser(26) and Ser(1105)). Mutation at these two sites (S26A and S1105A) of PLC-beta3 completely blocked the phosphorylation of PLC-beta3 protein catalyzed by PKG. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus |
| + |
CAMK2B |
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4.0
PLCB3
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