| + |
PRKCA | up-regulates 
phosphorylation
|
LRP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126958 |
Ser4517 |
LYMGGHGsRHSLAST |
Homo sapiens |
|
| pmid |
sentence |
| 15272003 |
Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase calpha regulates endocytosis and association with adaptor moleculesthese results indicate that elimination of serine and threonine phosphorylation sites in the lrp cytoplasmic domain reduces the extent of tyr63 phosphorylation and leads to impaired association with the adaptor protein shc. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-127207 |
Ser4520 |
GGHGSRHsLASTDEK |
Homo sapiens |
|
| pmid |
sentence |
| 15272003 |
Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase calpha regulates endocytosis and association with adaptor moleculesthese results indicate that elimination of serine and threonine phosphorylation sites in the lrp cytoplasmic domain reduces the extent of tyr63 phosphorylation and leads to impaired association with the adaptor protein shc. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-127211 |
Ser4523 |
GSRHSLAsTDEKREL |
Homo sapiens |
|
| pmid |
sentence |
| 15272003 |
Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase calpha regulates endocytosis and association with adaptor moleculesthese results indicate that elimination of serine and threonine phosphorylation sites in the lrp cytoplasmic domain reduces the extent of tyr63 phosphorylation and leads to impaired association with the adaptor protein shc. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-127215 |
Thr4460 |
GFQHQRMtNGAMNVE |
Homo sapiens |
|
| pmid |
sentence |
| 15272003 |
Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase calpha regulates endocytosis and association with adaptor moleculesthese results indicate that elimination of serine and threonine phosphorylation sites in the lrp cytoplasmic domain reduces the extent of tyr63 phosphorylation and leads to impaired association with the adaptor protein shc. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
PRKACA | up-regulates activity
phosphorylation
|
LRP1 |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250000 |
Ser4520 |
GGHGSRHsLASTDEK |
Cricetulus griseus |
|
| pmid |
sentence |
| 11158305 |
LRP phosphorylation is mediated by PKA at residue serine 76 of its cytoplasmic tail and that this phosphorylation contributes to receptor-mediated endocytosis. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
SRC | up-regulates
phosphorylation
|
LRP1 |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178159 |
Tyr4473 |
VEIGNPTyKMYEGGE |
Homo sapiens |
|
| pmid |
sentence |
| 18381291 |
The observation that the wild type protein was phosphorylated to a higher level than the y4473f mutant again indicates that phosphorylation of the tyr4473 residue by v-src is occurring in these cellsmutation of tyr4473 to alanine, which abolishes snx17 binding, resulted in impaired receptor recycling and reduced amounts of the mature form of lrp1 on the cell surface |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | up-regulates activity
phosphorylation
|
LRP1 |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101535 |
Tyr4507 |
TNFTNPVyATLYMGG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12789267 |
We recently observed that the ldl receptor-related protein 1 (lrp-1) is tyrosine phosphorylated in v-src-transformed cells.Of the four tyrosine residues present in the cytoplasmic domain of lrp-1, only tyr 63 is phosphorylated by v-src in vivo or in vitro. Using fibroblasts deficient in src, yes and fyn, we were able to show that there are multiple kinases present in the cell that can phosphorylate lrp-1. Tyrosine-phosphorylated lrp-1 associates with shc, a ptb and sh2 domain containing signaling protein that is involved in the activation of ras |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | down-regulates quantity by repression 
transcriptional regulation
|
LRP1 |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254461 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20980003 |
In the present study we report that specific silencing of either SREBP-1 or SREBP-2 enhanced LRP1 whereas overexpression of the active SREBP isoforms decreased LRP1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF1 | down-regulates quantity by repression
transcriptional regulation
|
LRP1 |
0.281 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254462 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20980003 |
In the present study we report that specific silencing of either SREBP-1 or SREBP-2 enhanced LRP1 whereas overexpression of the active SREBP isoforms decreased LRP1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SERPINC1 | up-regulates
binding
|
LRP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-41232 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8626456 |
In vitro binding studies revealed that antithrombin iii (atiii)thrombin, heparin cofactor ii (hcii)thrombin, and ?1-antitrypsin (?1AT)trypsin bound to purified lrp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SERPINA1 | up-regulates
binding
|
LRP1 |
0.328 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-41180 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8626456 |
In vitro binding studies revealed that antithrombin iii (atiii)thrombin, heparin cofactor ii (hcii)thrombin, and ?1-antitrypsin (?1AT)trypsin bound to purified lrp |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F2 | up-regulates
binding
|
LRP1 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-41090 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8626456 |
In vitro binding studies revealed that antithrombin iii (atiii)thrombin, heparin cofactor ii (hcii)thrombin, and ?1-antitrypsin (?1AT)trypsin bound to purified lrp |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
LRP1
- 
- 