Summary

Name LRP1
Full Name Prolow-density lipoprotein receptor-related protein 1
Synonyms LRP-1, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, APOER | A2MR, APR
Primary ID Q07954
Links - -
Type protein
Relations 12
Function Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:26142438, PubMed:1702392). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation LRP1 0.2
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LRP1 0.329
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates img/direct-activation.png phosphorylation LRP1 0.404
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LRP1 0.404
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP1 0.289
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation LRP1 0.283
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation LRP1 0.337
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP1 0.328
Publications: 1 Organism: Homo Sapiens