| + |
MFGE8 | up-regulates activity 
binding
|
Av/b3 integrin |
0.506 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260644 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 31958465 |
Milk fat globule-EGF factor 8 (MFGE8), a protein known as lactadherin in humans, contains C domains interacting with extracellular matrices and epidermal growth factor–like domains with an RGD motif binding to integrins αvβ3 and αvβ5. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
MFGE8 | up-regulates activity
binding
|
Av/b5 integrin |
0.523 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260645 |
|
|
Rattus norvegicus |
Fibroblast |
| pmid |
sentence |
| 31958465 |
Milk fat globule-EGF factor 8 (MFGE8), a protein known as lactadherin in humans, contains C domains interacting with extracellular matrices and epidermal growth factor–like domains with an RGD motif binding to integrins αvβ3 and αvβ5. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
MFGE8 | down-regulates activity 
|
p38 |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260651 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 19020771 |
In our current study, we have shown that after LPS-stimulation, MFG-E8-mediated apoptotic cell phagocytosis suppresses various ERK1/2, p38, JNK, and NFκB activation, resulting in a lower TNF-α release. We also explored whether MFG-E8 helps to suppress the proinflammatory pathway within RPMs. We hence incubated the macrophages with apoptotic cells and stimulated them with LPS and examined the activation of MAP kinase and NFkB pathways after the exogenous addition of recombinant MFG-E8 (rMFG-E8). While apoptotic cells alone had no effect on these pathways, the addition of rMFG-E8 to apoptotic cells prior to phagocytosis and LPS stimulation had a marked suppressive effect on all of the investigated pathways, particularly on the p38 and NFκB pathways that play a key role in the cytokine response of macrophages |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
MFGE8 | down-regulates
|
Fibrosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260646 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 31958465 |
We demonstrated that Milk fat globule-EGF factor8 (MFGE8) is protective against Ang-II-induced atrial fibrosis and atrial fibrillation. In vitro, silencing of MFGE8 by small interfering RNA significantly increased Ang-II-induced atrial fibrosis, whereas administration of recombinant human MFGE8 (rhMFGE8) attenuated the atrial fibrosis. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
MFGE8 | up-regulates quantity by expression 
transcriptional regulation
|
SOCS3 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260653 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21901532 |
In an attempt to clarify the direct anti-inflammatory role of MFG-E8, we revealed a distinct signaling pathway where MFG-E8 activates suppressor of cytokine signaling (SOCS) 3 gene expression via STAT3 mediated pathway, which in turn served as a negative regulator for LPS induced TLR4 signaling by targeting NF-κB p65 component, thereby attenuating the down-stream signaling for TNF-α production |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MFGE8 | up-regulates quantity by expression
|
GRK2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260648 |
|
|
Mus musculus |
Lung |
| pmid |
sentence |
| 22634615 |
Our findings showed MFG-E8–mediated upregulation of GRK2, which can be correlated with reduction of surface CXCR2. The MFG-E8 effect is mediated by αvβ3 integrin to upregulate GRK2 expression and results in downregulation of surface CXCR2 levels in neutrophils, leading to decrease of neutrophil migration |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MFGE8 | down-regulates quantity by repression
transcriptional regulation
|
TNF |
0.317 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260650 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22114683 |
Our study demonstrated the direct anti-inflammatory role of MFG-E8 in terms of attenuating TNF-α production in mouse peritoneal macrophages and RAW264.7 cells treated with LPS |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MFGE8 | down-regulates quantity by repression
transcriptional regulation
|
IL1B |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260649 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23454767 |
We show that MFGE8 is an endogenous inhibitor of inflammasome-induced IL-1β production. MFGE8 inhibited necrotic cell–induced and ATP-dependent IL-1β production by macrophages through mediation of integrin β3 and P2X7 receptor interactions in primed cells. In conclusion, we demonstrated that MFGE8 regulates innate immunity through inhibition of inflammasome-induced IL-1β production. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MFGE8 | up-regulates activity
|
STAT3 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260654 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21901532 |
In an attempt to clarify the direct anti-inflammatory role of MFG-E8, we revealed a distinct signaling pathway where MFG-E8 activates suppressor of cytokine signaling (SOCS) 3 gene expression via STAT3 mediated pathway, which in turn served as a negative regulator for LPS induced TLR4 signaling by targeting NF-κB p65 component, thereby attenuating the down-stream signaling for TNF-α production |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MFGE8 | down-regulates activity
|
NfKb-p65/p50 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260652 |
|
|
Rattus norvegicus |
Macrophage |
| pmid |
sentence |
| 19020771 |
In our current study, we have shown that after LPS-stimulation, MFG-E8-mediated apoptotic cell phagocytosis suppresses various ERK1/2, p38, JNK, and NFκB activation, resulting in a lower TNF-α release. We also explored whether MFG-E8 helps to suppress the proinflammatory pathway within RPMs. We hence incubated the macrophages with apoptotic cells and stimulated them with LPS and examined the activation of MAP kinase and NFkB pathways after the exogenous addition of recombinant MFG-E8 (rMFG-E8). While apoptotic cells alone had no effect on these pathways, the addition of rMFG-E8 to apoptotic cells prior to phagocytosis and LPS stimulation had a marked suppressive effect on all of the investigated pathways, particularly on the p38 and NFκB pathways that play a key role in the cytokine response of macrophages |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
3.0
MFGE8
- 
- 