Summary

Name SOCS3
Full Name Suppressor of cytokine signaling 3
Synonyms SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SSI-3 | CIS3, SSI3
Primary ID O14543
Links - -
Type protein
Relations 18
Pathways IL6 Signaling, Leptin Signaling, Macrophage: Polarization and myogenesis, Myofiber: IL6 and atrophy, Satellite: IL6
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820).

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding JAK1 0.721
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ down-regulates img/indirect_inhibition.png NfKb-p65/p50 0.402
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png STAT3 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling, Leptin Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOCS3 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling, Leptin Signaling
+ down-regulates activity img/direct_inhibition.png binding JAK3 0.685
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SOCS3 0.667
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOCS3 0.358
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SOCS3 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling, Leptin Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png binding SIGLEC7 0.38
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/indirect_inhibition.png STAT3 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling, Leptin Signaling
+ down-regulates activity img/direct_inhibition.png binding JAK2 0.789
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ up-regulates quantity img/direct-activation.png binding Elongin E3-Cul-5 0.635
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SOCS3 0.622
Publications: 1 Organism: Mus Musculus
Pathways:Leptin Signaling
+ down-regulates activity img/direct_inhibition.png binding IL6ST 0.634
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IL6 Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOCS3 0.287
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SOCS3 0.402
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding IRS1 0.73
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling