| + |
SOCS3 | down-regulates 
|
NfKb-p65/p50 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253052 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16543409 |
Suppressor of cytokine signaling (SOCS)-3 was shown to inhibit IL-1-induced transcription and activation of NFkappaB and the MAPKs JNK and p38, but the mechanism is unknown |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates quantity by expression 
transcriptional regulation
|
SOCS3 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253050 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11159537 |
STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling, Leptin Signaling |
| + |
SOCS3 | down-regulates activity 
binding
|
JAK1 |
0.722 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253051 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23454976 |
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling |
| + |
SOCS3 | down-regulates activity
binding
|
IL6ST |
0.637 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255328 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23454976 |
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. The inhibitory protein SOCS3 plays a key part in the immune and hematopoietic systems by regulating signaling induced by specific cytokines. SOCS3 functions by inhibiting the catalytic activity of Janus kinases (JAKs) that initiate signaling within the cell. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202045 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19620279 |
We now show that SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by specifically inhibiting the LIF-induced JAK1/STAT1/STAT3 pathway via distinct targets; whereas SOCS1 and SOCS3 selectively bind and inhibit JAK1 and gp130, respectively, PIAS1 targets mainly the activated STAT1 and prevents its binding to DNA. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | IL6 Signaling |
| + |
SOCS3 | down-regulates
binding
|
IRS1 |
0.73 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199361 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23115649 |
Irs-1 is the major signaling protein that socs3 targets to inhibit insulin signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
| + |
STAT1 | up-regulates quantity by expression 
transcriptional regulation
|
SOCS3 |
0.666 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249565 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19643666 |
Expression of SOCS1 and SOCS3 is regulated primarily by activation of STAT1 and STAT3, respectively, although their expression can be mediated through other signaling cascades, including the mitogen activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappaB) pathways. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOCS3 | up-regulates quantity
binding
|
Elongin E3-Cul-5 |
0.638 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272643 |
|
|
Mus musculus |
BA/F3 Cell |
| pmid |
sentence |
| 17138568 |
SOCS proteins can act as E3 ligases by forming a complex with Elongin B/C and Cul5/Rbx1/2.SOCS3 targets Siglec 7 for degradation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
SOCS3 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249566 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19643666 |
Expression of SOCS1 and SOCS3 is regulated primarily by activation of STAT1 and STAT3, respectively, although their expression can be mediated through other signaling cascades, including the mitogen activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappaB) pathways. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOCS3 | down-regulates activity
binding
|
JAK3 |
0.687 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238645 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21508344 |
SOCS proteins bind to janus kinase and to certain cytokine receptors and signaling molecules, thereby suppressing further signaling events. Studies have shown that SOCS proteins are key physiological regulators of inflammation. Recent studies have also demonstrated that SOCS1 and SOCS3 are important regulators of adaptive immunity.Both SOCS1 and SOCS3 can inhibit JAK tyrosine kinase activity directly through their kinase inhibitory regions (KIR). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOCS3 | down-regulates quantity by destabilization
binding
|
SIGLEC7 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272642 |
|
|
Mus musculus |
BA/F3 Cell |
| pmid |
sentence |
| 17138568 |
SOCS proteins can act as E3 ligases by forming a complex with Elongin B/C and Cul5/Rbx1/2.SOCS3 targets Siglec 7 for degradation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FLT3 | up-regulates quantity by expression
transcriptional regulation
|
SOCS3 |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261546 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12468433 |
We have also found SOCS2 and SOCS3 specifically induced in 32D/Flt3-ITD, both of which are STAT3/5 target genes and known negative regulators of receptor signaling |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOCS3 | down-regulates
|
STAT3 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249567 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 21628332 |
SOCS3 attenuates IL-6-induced STAT3 anti-inflammatory effects, as well as IL-4-induced insulin receptor substrate-2/PI3K-mediated gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling, Leptin Signaling |
| + |
MFGE8 | up-regulates quantity by expression
transcriptional regulation
|
SOCS3 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260653 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21901532 |
In an attempt to clarify the direct anti-inflammatory role of MFG-E8, we revealed a distinct signaling pathway where MFG-E8 activates suppressor of cytokine signaling (SOCS) 3 gene expression via STAT3 mediated pathway, which in turn served as a negative regulator for LPS induced TLR4 signaling by targeting NF-κB p65 component, thereby attenuating the down-stream signaling for TNF-α production |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOCS3 | down-regulates activity
binding
|
JAK2 |
0.789 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255329 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24600449 |
The ability of SOCS3 to simultaneously bind to JAK and to the cytokine receptor explains the specificity of the suppression. SOCS3 binds JAK and gp130 receptor simultaneously, using two opposing surfaces: while the phosphotyrosine-binding groove on the SOCS3 SH2 domain is occupied by the gp130 receptor, a subdomain in the SH2 domain of SOCS3 is also required for inhibition of JAK, binding in a phospho-independent manner to a non-canonical surface of JAK2 (58, 59). The KIR of SOCS3 occludes the substrate-binding groove on JAK2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
SOCS3 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253583 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12565872 |
We also found that the wild type SOCS-3 promoter construct has significantly greater activity in non-small-cell lung cancer cell lines than in normal cells in accordance with STAT3 disregulation in these cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling, Leptin Signaling |
| + |
SOCS3 | down-regulates activity
|
STAT3 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255330 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24600449 |
A main role of SOCS3 results from its binding to both the JAK kinase and the cytokine receptor, which results in the inhibition of STAT3 activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling, Leptin Signaling |
| + |
STAT5A | up-regulates quantity by expression
transcriptional regulation
|
SOCS3 |
0.623 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261548 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12468433 |
We have also found SOCS2 and SOCS3 specifically induced in 32D/Flt3-ITD, both of which are STAT3/5 target genes and known negative regulators of receptor signaling |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Leptin Signaling |
3.0
SOCS3
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