Summary

Name KLF1
Full Name Krueppel-like factor 1
Synonyms Erythroid krueppel-like transcription factor, EKLF | EKLF
Primary ID Q13351
Links - -
Type protein
Relations 12
Pathways HaematopoiesisTranscriptionalControl
Function Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png acetylation KLF1 0.507
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KLF1 0.348
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation KLF1 0.349
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding FLI1 0.379
Publications: 1 Organism: Mus Musculus
Pathways:HaematopoiesisTranscriptionalControl
+ down-regulates activity img/direct_inhibition.png binding KLF1 0.379
Publications: 1 Organism: Mus Musculus
Pathways:HaematopoiesisTranscriptionalControl
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBB 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDKN2C 0.269
Publications: 1 Organism: Drosophila Melanogaster
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF1 0.523
Publications: 1 Organism: Mus Musculus
Pathways:HaematopoiesisTranscriptionalControl
+ up-regulates activity img/direct-activation.png acetylation KLF1 0.475
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KLF8 0.254
Publications: 1 Organism: Mus Musculus
Tissue: Liver
+ up-regulates img/indirect-activation.png Erythrocyte_differentiation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:HaematopoiesisTranscriptionalControl
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF1 0.447
Publications: 1 Organism: Mus Musculus
Pathways:HaematopoiesisTranscriptionalControl