3.0
Macrophage: IL10
Pathway ID: SIGNOR-MacroIL10
Description: Interleukin-10 (IL10) is an anti-inflammatory cytokine with important immunoregulatory functions. It is primarily secreted by antigen-presenting cells such as activated T-cells, monocytes, B-cells and macrophages. In macrophages, IL10 pathway drives the M2c polarization. M2c macrophages have potent anti-inflammatory functions, being able to secrete TGF beta and IL10, thus establishing a positive feedback loop for IL10. IL10 binds its receptor and activates the phosphorylation of receptor-associated Janus Kinase-1 (JAK1) and Tyrosine Kinase-2 (TYK2), hence activating STAT3, which in turn translocates into the nucleus where it binds, with high affinity, the promoters of various IL10-responsive genes. IL10 production is positively regulated by STAT3 transcription factor which allows the trascription of several genes, including IL10, TGF beta and Mrc1, among others. FLI1 is also required to promote the expression of IL10. To maintain a pro-inflammatory state, IL10 transcription is downregulated by IRF5.
Curated by: Alessandro Palma
Description: Interleukin-10 (IL10) is an anti-inflammatory cytokine with important immunoregulatory functions. It is primarily secreted by antigen-presenting cells such as activated T-cells, monocytes, B-cells and macrophages. In macrophages, IL10 pathway drives the M2c polarization. M2c macrophages have potent anti-inflammatory functions, being able to secrete TGF beta and IL10, thus establishing a positive feedback loop for IL10. IL10 binds its receptor and activates the phosphorylation of receptor-associated Janus Kinase-1 (JAK1) and Tyrosine Kinase-2 (TYK2), hence activating STAT3, which in turn translocates into the nucleus where it binds, with high affinity, the promoters of various IL10-responsive genes. IL10 production is positively regulated by STAT3 transcription factor which allows the trascription of several genes, including IL10, TGF beta and Mrc1, among others. FLI1 is also required to promote the expression of IL10. To maintain a pro-inflammatory state, IL10 transcription is downregulated by IRF5.
Curated by: Alessandro Palma
