+ |
PRKCD | up-regulates activity
phosphorylation
|
KLF5 |
0.341 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249206 |
Ser153 |
LRTGLYKsQRPCVTH |
Homo sapiens |
HEC-1-B Cell |
pmid |
sentence |
12682370 |
Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function. | Inhibition of protein kinase activity by H7 or calphostin C blocked both full-length and N-terminal fragment (amino acids 1-238) KLF5 activities. Mutation at a potential protein kinase C phosphorylation site within the CBP interaction domain of KLF5 reduces its transactivation function. Furthermore, using the GST pull-down approach, we showed that phosphorylation of KLF5 enhances its interaction with CBP. The results of the present study provide a mechanism for KLF5 transactivation function. | We found that KLF5s activity was reduced to half when the serine in the potential PKC phosphorylation site was mutated to alanine (Fig. 6B, S153A) Nonetheless, the S153A mutant still retains significant transactivation activity. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
GSK3B | down-regulates
phosphorylation
|
KLF5 |
0.375 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-203627 |
Ser303 |
QATYFPPsPPSSEPG |
Homo sapiens |
|
pmid |
sentence |
24398687 |
Stability of the klf5 is mediated by proteasomal degradation via phosphorylation by glycogen synthase kinase 3_ (gsk3_) and recognition by f-box and wd repeat domain-containing 7 (fbw7) of a phosphodegron sequence surrounding serine 303 in klf5 |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Adipogenesis |
+ |
TRIM25 | down-regulates quantity by destabilization
polyubiquitination
|
KLF5 |
0.495 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271908 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
pmid |
sentence |
21542805 |
The oestrogen-inducible E3 ligase EFP (oestrogen-responsive finger protein) was identified as a key player in oestrogen-mediated degradation of KLF5, as knockdown and overexpression of EFP increased and decreased KLF5 protein levels respectively, and the decrease continued even when protein synthesis was blocked. |
|
Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
+ |
NR3C1 | up-regulates quantity by expression
transcriptional regulation
|
KLF5 |
0.297 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-256118 |
|
|
Mus musculus |
Preadipocyte Cell Line |
pmid |
sentence |
27777311 |
We show that in addition, DEX-bound GR directly promotes the expression of adipogenic TFs, including C/EBPβ, Klf5, Klf9, and C/EBPα |
|
Publications: |
1 |
Organism: |
Mus Musculus |
Pathways: | Adipogenesis |
+ |
KLF5 | up-regulates
transcriptional regulation
|
PPARG |
0.607 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-210010 |
|
|
Mus musculus |
|
pmid |
sentence |
16054042 |
Klf5 expression is induced by c/ebpbeta and delta. KLF5, in turn, acts in concert with c/ebpbeta/delta to activate the ppargamma2 promoter. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
Pathways: | Adipogenesis |
+ |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
KLF5 |
0.691 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-210004 |
|
|
Mus musculus |
|
pmid |
sentence |
16054042 |
Klf5 expression is induced by c/ebpbeta and delta. KLF5, in turn, acts in concert with c/ebpbeta/delta to activate the ppargamma2 promoter. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
Pathways: | Adipogenesis |
+ |
CEBPD | up-regulates quantity by expression
transcriptional regulation
|
KLF5 |
0.504 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-210007 |
|
|
Mus musculus |
|
pmid |
sentence |
16054042 |
Klf5 expression is induced by c/ebpbeta and delta. KLF5, in turn, acts in concert with c/ebpbeta/delta to activate the ppargamma2 promoter. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
Pathways: | Adipogenesis |