| + |
CDK9 | up-regulates activity 
phosphorylation
|
NCOA2 |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256096 |
Ser469 |
NYALKMNsPSQSSPG |
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 29170386 |
Interestingly, GRIP1 is phosphorylated at an N-terminal serine cluster by cyclin-dependent kinase-9 (CDK9), which is recruited into GC-induced GR:GRIP1:CDK9 hetero-complexes, producing distinct GRE-specific GRIP1 phospho-isoforms. Phosphorylation potentiates GRIP1 coactivator but, remarkably, not its corepressor properties. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256097 |
Ser487 |
GQPTSMLsPRHRMSP |
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 29170386 |
Interestingly, GRIP1 is phosphorylated at an N-terminal serine cluster by cyclin-dependent kinase-9 (CDK9), which is recruited into GC-induced GR:GRIP1:CDK9 hetero-complexes, producing distinct GRE-specific GRIP1 phospho-isoforms. Phosphorylation potentiates GRIP1 coactivator but, remarkably, not its corepressor properties. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256098 |
Ser493 |
LSPRHRMsSPGVAGS |
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 29170386 |
Interestingly, GRIP1 is phosphorylated at an N-terminal serine cluster by cyclin-dependent kinase-9 (CDK9), which is recruited into GC-induced GR:GRIP1:CDK9 hetero-complexes, producing distinct GRE-specific GRIP1 phospho-isoforms. Phosphorylation potentiates GRIP1 coactivator but, remarkably, not its corepressor properties. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256099 |
Ser499 |
MSPGVAGsPRIPPSQ |
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 29170386 |
Interestingly, GRIP1 is phosphorylated at an N-terminal serine cluster by cyclin-dependent kinase-9 (CDK9), which is recruited into GC-induced GR:GRIP1:CDK9 hetero-complexes, producing distinct GRE-specific GRIP1 phospho-isoforms. Phosphorylation potentiates GRIP1 coactivator but, remarkably, not its corepressor properties. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
NCOA2 | up-regulates
binding
|
RXRA |
0.788 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114847 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11851396 |
Here, it is demonstrated that mutation of the h11 phenylalanine residues diminishes the ability of rxr to associate with the p160 coactivators tif2 and p/cip, but has little effect on ligand-dependent interactions of the receptor with the unrelated coactivator tif1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ESR1 | up-regulates quantity by expression 
transcriptional regulation
|
NCOA2 |
0.81 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109520 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11477071 |
Er_ mutants unable to bind coactivators drastically decrease estradiol regulation of ap-1-mediated transcription and overexpression of the coactivator grip1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA2 | up-regulates activity
binding
|
AR |
0.898 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251530 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24239470 |
The NCOA2 gene encodes a transcriptional coactivator (SRC-2) that modulates gene expression by hormone receptors, including AR. NCOA2 is both amplified and rarely mutated in prostate cancers, with higher NCOA2 levels resulting in increased androgen signaling readout. Furthermore, as mentioned previously, SRC-3, a close homolog encoded by NCOA3, is a substrate of SPOP whose protein levels are increased by SPOP mutation, potentially linking these common point mutations to the androgen axis |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251531 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24239470 |
The NCOA2 gene encodes a transcriptional coactivator (SRC-2) that modulates gene expression by hormone receptors, including AR. NCOA2 is both amplified and rarely mutated in prostate cancers, with higher NCOA2 levels resulting in increased androgen signaling readout. Furthermore, as mentioned previously, SRC-3, a close homolog encoded by NCOA3, is a substrate of SPOP whose protein levels are increased by SPOP mutation, potentially linking these common point mutations to the androgen axis |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Prostate Cancer |
| + |
NCOA2 | up-regulates activity
binding
|
NR3C1 |
0.832 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256095 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 29170386 |
Here we report that GRIP1 loss in macrophages attenuates glucocorticoid induction of several anti-inflammatory targets, and that GC treatment of quiescent macrophages globally directs GRIP1 toward GR binding sites dominated by palindromic GC response elements (GRE), suggesting a non-redundant GRIP1 function as a GR coactivator. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NCOA2 | up-regulates
binding
|
PPARG |
0.759 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179175 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18584035 |
Collectively, our data provide the first evidence that erbeta-deficiency protects against diet-induced ir and glucose intolerance which involves an augmented ppargamma signaling in adipose tissue. Moreover, our data suggest that the coactivators src1 and tif2 are involved in this interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Prostate Cancer |
| + |
NCOA2 | up-regulates
binding
|
RARA |
0.615 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96827 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12503607 |
Transcriptional coactivator for steroid receptors and nuclear receptors.nteracts with casp8ap2 and ttll5/stamp. Interacts with esr1, rara and rxra. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NCOA2
- 
- 