Summary

Name SCN9A
Full Name Sodium channel protein type 9 subunit alpha
Synonyms Neuroendocrine sodium channel, hNE-Na, Peripheral sodium channel 1, PN1, Sodium channel protein type IX subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.7 | NENA
Primary ID Q15858
Links - -
Type protein
Relations 15
Function Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SCN9A 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination SCN9A 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN9A 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Spinal Ganglion
+ down-regulates activity img/direct_inhibition.png binding SCN9A 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN9A 0.14
Publications: 1 Organism: Rattus Norvegicus
Tissue: Spinal Ganglion
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN9A 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Spinal Ganglion
+ down-regulates activity img/direct_inhibition.png binding SCN9A 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SCN9A 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SCN9A 0.14
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png binding SCN9A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SCN9A 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Action potential 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png SCN9A 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding SCN9A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization sodium ion 0.14
Publications: 1 Organism: Homo Sapiens